SPATIAL DISTRIBUTION OF NEWBORNS WITH SICKLE CELL TRAIT IN SERGIPE, BRAZIL.
Journal
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
ISSN: 1984-0462
Titre abrégé: Rev Paul Pediatr
Pays: Brazil
ID NLM: 9109353
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
09
2018
accepted:
18
01
2019
entrez:
12
3
2020
pubmed:
12
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
To use the spatial distribution of the sickle cell trait (SCT) to analyze the frequency of hemoglobin S (HbS) carriers in Sergipe. The sample consisted of all individuals born in Sergipe from October 2011 to October 2012 who underwent neonatal screening in the public health system. Tests were carried out in basic health units and forwarded to the University Hospital laboratory, where they were analyzed. We used spatial autocorrelation (Moran's index) to assess the spatial distribution of heterozygous individuals with hemoglobinopathies. Among 32,906 newborns, 1,202 showed other types of hemoglobin besides Hemoglobin A. We found a positive correlation between the percentage of black and multiracial people and the incidence of SCT. Most SCT cases occurred in the cities of Aracaju (n=273; 22.7%), Nossa Senhora do Socorro (n=102; 8.4%), São Cristóvão (n=58; 4.8%), Itabaiana (n=39; 4.2%), Lagarto (n=37; 4.01%), and Estância (n=46; 4.9%). The spatial distribution analysis identified regions in the state with a high frequency of HbS carriers. This information is important health care planning. This method can be applied to detect other places that need health units to guide and care for sickle cell disease patients and their families.
Identifiants
pubmed: 32159643
pii: S0103-05822020000100427
doi: 10.1590/1984-0462/2020/38/2018229
pmc: PMC7063597
pii:
doi:
Substances chimiques
Hemoglobin, Sickle
0
Types de publication
Journal Article
Langues
eng
por
Sous-ensembles de citation
IM
Pagination
e2018229Références
Trop Med Int Health. 2010 Oct;15(10):1125-31
pubmed: 20701727
Eur J Hum Genet. 2012 May;20(5):486-7
pubmed: 22378289
Rev Bras Hematol Hemoter. 2011;33(1):49-54
pubmed: 23284244
Am J Epidemiol. 2000 May 1;151(9):839-45
pubmed: 10791557
Rev Bras Epidemiol. 2017 Oct-Dec;20(4):702-713
pubmed: 29267754
Cad Saude Publica. 2005 Jan-Feb;21(1):292-8
pubmed: 15692663
Cien Saude Colet. 2015 Sep;20(9):2779-86
pubmed: 26331509
Am J Med. 2009 Jun;122(6):507-12
pubmed: 19393983
BMJ. 1990 Feb 10;300(6721):371-4
pubmed: 2106991
J Inherit Metab Dis. 2007 Aug;30(4):615
pubmed: 17694357
Hematology Am Soc Hematol Educ Program. 2015;2015:160-7
pubmed: 26637716
Rev Bras Hematol Hemoter. 2017 Jan - Mar;39(1):52-56
pubmed: 28270347
Lancet. 2013 Jan 12;381(9861):142-51
pubmed: 23103089
Haematologica. 2015 Sep;100(9):1108-16
pubmed: 26341524
Rev Bras Hematol Hemoter. 2012;34(5):392-3
pubmed: 23125548
Br Med J (Clin Res Ed). 1986 Mar 15;292(6522):737-40
pubmed: 3082419
Cien Saude Colet. 2011;16 Suppl 1:1289-94
pubmed: 21503478
Hist Cienc Saude Manguinhos. 2005 May-Aug;12(2):419-46
pubmed: 16353393
Cien Saude Colet. 2010 Jun;15 Suppl 1:1733-40
pubmed: 20640335
Cad Saude Publica. 2004 Jan-Feb;20(1):123-8
pubmed: 15029312
Cad Saude Publica. 2012 Jun;28(6):1067-77
pubmed: 22666811