Adaptations of Interferon Regulatory Factor 3 with Transition from Terrestrial to Aquatic Life.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 03 2020
11 03 2020
Historique:
received:
28
09
2019
accepted:
10
02
2020
entrez:
13
3
2020
pubmed:
13
3
2020
medline:
21
11
2020
Statut:
epublish
Résumé
Interferon regulatory factor 3 (IRF3) and IRF7 are closely related IRF members and the major factors for the induction of interferons, a key component in vertebrate innate immunity. However, there is limited knowledge regarding the evolution and adaptation of those IRFs to the environments. Two unique motifs in IRF3 and 7 were identified. One motif, GASSL, is highly conserved throughout the evolution of IRF3 and 7 and located in the signal response domain. Another motif, DPHK, is in the DNA-binding domain. The ancestral protein of IRF3 and 7 seemed to possess the DPHK motif. In the ray-finned fish lineage, while the DPHK is maintained in IRF7, the motif in IRF3 is changed to NPHK with a D → N amino acid substitution. The D → N substitution are also found in amphibian IRF3 but not in amphibian IRF7. Terrestrial animals such as reptiles and mammals predominantly use DPHK sequences in both IRF3 and 7. However, the D → N substitution in IRF3 DPHK is again found in cetaceans such as whales and dolphins as well as in marsupials. These observations suggest that the D → N substitutions in the IRF3 DPHK motif is likely to be associated with vertebrate's adaptations to aquatic environments and other environmental changes.
Identifiants
pubmed: 32161340
doi: 10.1038/s41598-020-61365-9
pii: 10.1038/s41598-020-61365-9
pmc: PMC7066157
doi:
Substances chimiques
Interferon Regulatory Factor-3
0
Interferon Regulatory Factor-7
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4508Références
EMBO J. 1998 Feb 16;17(4):1087-95
pubmed: 9463386
Mol Cell Biol. 2000 Dec;20(23):8803-14
pubmed: 11073981
Nature. 2014 Sep 4;513(7516):54-8
pubmed: 25162530
Genes Immun. 2011 Sep;12(6):399-414
pubmed: 21490621
Dev Comp Immunol. 2018 Apr;81:324-333
pubmed: 29253557
ISME J. 2012 Feb;6(2):273-84
pubmed: 21833038
Biol Rev Camb Philos Soc. 2014 Nov;89(4):950-71
pubmed: 24612207
J Interferon Cytokine Res. 2002 Jan;22(1):49-58
pubmed: 11846975
J Biol Chem. 1998 Oct 30;273(44):29210-7
pubmed: 9786932
Viruses. 2016 Nov 02;8(11):
pubmed: 27827855
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Nature. 2014 Jan 9;505(7482):174-9
pubmed: 24402279
Clin Microbiol Rev. 2001 Oct;14(4):778-809, table of contents
pubmed: 11585785
J Immunol. 2015 Dec 15;195(12):5657-66
pubmed: 26573836
Immunol Lett. 2015 Apr;164(2):55-64
pubmed: 25712467
Fish Shellfish Immunol. 2018 Feb;73:145-151
pubmed: 29246809
J Interferon Cytokine Res. 2011 Dec;31(12):857-65
pubmed: 22149411
Science. 2015 Mar 13;347(6227):aaa2630
pubmed: 25636800
Front Immunol. 2017 Mar 02;8:209
pubmed: 28303139
Nat Struct Biol. 2003 Nov;10(11):913-21
pubmed: 14555996
Dev Comp Immunol. 2010 Aug;34(8):855-65
pubmed: 20363250
Trends Biochem Sci. 2005 Feb;30(2):66-9
pubmed: 15691650
Mol Biol Evol. 2019 Aug 1;36(8):1746-1763
pubmed: 31070747
J Immunol. 2015 Jul 1;195(1):289-97
pubmed: 25994966
Cell. 2007 Jun 15;129(6):1111-23
pubmed: 17574024
Nature. 2007 Dec 20;450(7173):1190-4
pubmed: 18097400
Science. 1994 Jun 3;264(5164):1415-21
pubmed: 8197455
J Biol Chem. 2004 Mar 12;279(11):9698-702
pubmed: 14703513
Front Immunol. 2017 Jan 31;8:49
pubmed: 28197148
Immunity. 2006 Sep;25(3):349-60
pubmed: 16979567
Genome Res. 2004 Jun;14(6):1188-90
pubmed: 15173120
Nucleic Acids Res. 2006;34(15):4160-7
pubmed: 16935875
Front Immunol. 2019 May 24;10:1176
pubmed: 31178872
BMC Genomics. 2017 Jan 30;18(1):87
pubmed: 28132643
EMBO J. 1998 Nov 16;17(22):6660-9
pubmed: 9822609
Annu Rev Immunol. 2008;26:535-84
pubmed: 18303999
Front Immunol. 2019 Jul 12;10:1558
pubmed: 31354716
Nat Rev Immunol. 2015 Feb;15(2):87-103
pubmed: 25614319
Nucleic Acids Res. 2018 Jul 2;46(W1):W296-W303
pubmed: 29788355
Annu Rev Biochem. 2004;73:1019-49
pubmed: 15189166
Front Microbiol. 2016 Mar 14;7:313
pubmed: 27014235
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
Brief Bioinform. 2019 Jul 19;20(4):1160-1166
pubmed: 28968734
Genes Cells. 2010 Aug;15(8):901-10
pubmed: 20604809
Semin Cancer Biol. 2001 Dec;11(6):445-53
pubmed: 11669606
Dev Comp Immunol. 2012 Jun;37(2):213-20
pubmed: 22504164
Nature. 2005 Apr 7;434(7034):772-7
pubmed: 15800576
Mol Biol Evol. 2017 Sep 1;34(9):2422-2424
pubmed: 28472384
Nat Rev Rheumatol. 2010 Jan;6(1):40-9
pubmed: 20046205
J Interferon Cytokine Res. 2002 Jan;22(1):95-101
pubmed: 11846980
Zoolog Sci. 2015 Jan;32(1):1-7
pubmed: 25660690
J Morphol. 2014 Jul;275(7):822-39
pubmed: 24469962
Bioinformatics. 2011 Feb 1;27(3):343-50
pubmed: 21134891
BMC Immunol. 2010 May 05;11:22
pubmed: 20444275
Expert Opin Drug Discov. 2014 Jul;9(7):725-39
pubmed: 24836096
BMC Bioinformatics. 2009 Dec 15;10:421
pubmed: 20003500
J Mol Biol. 1990 Oct 5;215(3):403-10
pubmed: 2231712
Mol Cell Biol. 2000 Jun;20(11):4159-68
pubmed: 10805757
Syst Biol. 2010 May;59(3):307-21
pubmed: 20525638
Biopolymers. 1998;47(3):243-61
pubmed: 9817027
Nat Ecol Evol. 2017 Sep;1(9):1370-1378
pubmed: 28890940
Mol Cell. 1998 Mar;1(4):507-18
pubmed: 9660935
Annu Rev Microbiol. 2001;55:255-81
pubmed: 11544356
Integr Comp Biol. 2013 Aug;53(2):192-6
pubmed: 23660589
Mol Biol Evol. 2009 Nov;26(11):2539-50
pubmed: 19638535