Metabolic determinants of lupus pathogenesis.
Amino Acids
/ metabolism
Animals
Autoimmunity
Basic Helix-Loop-Helix Transcription Factors
/ metabolism
Biomarkers
Cholesterol
/ metabolism
Disease Susceptibility
Energy Metabolism
/ drug effects
Fatty Acids
/ metabolism
Homeostasis
Humans
Lipid Metabolism
Lupus Erythematosus, Systemic
/ drug therapy
Oxidation-Reduction
Oxidative Phosphorylation
Signal Transduction
TOR Serine-Threonine Kinases
/ metabolism
glucose
glutamine
lupus
metabolic inhibitors
metabolism
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
03
01
2020
revised:
20
02
2020
accepted:
24
02
2020
pubmed:
13
3
2020
medline:
4
6
2021
entrez:
13
3
2020
Statut:
ppublish
Résumé
The metabolism of healthy murine and more recently human immune cells has been investigated with an increasing amount of details. These studies have revealed the challenges presented by immune cells to respond rapidly to a wide variety of triggers by adjusting the amount, type, and utilization of the nutrients they import. A concept has emerged that cellular metabolic programs regulate the size of the immune response and the plasticity of its effector functions. This has generated a lot of enthusiasm with the prediction that cellular metabolism could be manipulated to either enhance or limit an immune response. In support of this hypothesis, studies in animal models as well as human subjects have shown that the dysregulation of the immune system in autoimmune diseases is associated with a skewing of the immunometabolic programs. These studies have been mostly conducted on autoimmune CD4
Identifiants
pubmed: 32162304
doi: 10.1111/imr.12847
pmc: PMC7180129
mid: NIHMS1574199
doi:
Substances chimiques
Amino Acids
0
Basic Helix-Loop-Helix Transcription Factors
0
Biomarkers
0
Fatty Acids
0
Cholesterol
97C5T2UQ7J
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-186Subventions
Organisme : NIAID NIH HHS
ID : R01 AI045050
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI128901
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI045050
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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