Magnetic core-shell nanowires as MRI contrast agents for cell tracking.
Cell labeling
Cell tracking
Core–shell
Iron-iron oxide
Magnetic resonance imaging
Nanowires
T2 contrast
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
12 Mar 2020
12 Mar 2020
Historique:
received:
16
12
2019
accepted:
27
02
2020
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Identifying the precise location of cells and their migration dynamics is of utmost importance for achieving the therapeutic potential of cells after implantation into a host. Magnetic resonance imaging is a suitable, non-invasive technique for cell monitoring when used in combination with contrast agents. This work shows that nanowires with an iron core and an iron oxide shell are excellent materials for this application, due to their customizable magnetic properties and biocompatibility. The longitudinal and transverse magnetic relaxivities of the core-shell nanowires were evaluated at 1.5 T, revealing a high performance as T Iron-iron oxide core-shell nanowires enabled the efficient and longitudinal cellular detection through magnetic resonance imaging acting as T
Sections du résumé
BACKGROUND
BACKGROUND
Identifying the precise location of cells and their migration dynamics is of utmost importance for achieving the therapeutic potential of cells after implantation into a host. Magnetic resonance imaging is a suitable, non-invasive technique for cell monitoring when used in combination with contrast agents.
RESULTS
RESULTS
This work shows that nanowires with an iron core and an iron oxide shell are excellent materials for this application, due to their customizable magnetic properties and biocompatibility. The longitudinal and transverse magnetic relaxivities of the core-shell nanowires were evaluated at 1.5 T, revealing a high performance as T
CONCLUSIONS
CONCLUSIONS
Iron-iron oxide core-shell nanowires enabled the efficient and longitudinal cellular detection through magnetic resonance imaging acting as T
Identifiants
pubmed: 32164746
doi: 10.1186/s12951-020-00597-3
pii: 10.1186/s12951-020-00597-3
pmc: PMC7069006
doi:
Substances chimiques
Ferric Compounds
0
Magnetite Nanoparticles
0
ferric oxide
1K09F3G675
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
42Subventions
Organisme : Agencia Estatal de Investigación
ID : BIO2016-77367-R
Organisme : Agencia Estatal de Investigación
ID : SAF2017-87670-R
Organisme : Agencia Estatal de Investigación
ID : MDM-2017-0720
Organisme : Eusko Jaurlaritza
ID : KK-2017/00008
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