In-situ forming chitosan implant-loaded with raloxifene hydrochloride and bioactive glass nanoparticles for treatment of bone injuries: Formulation and biological evaluation in animal model.
Animals
Bone Density Conservation Agents
/ administration & dosage
Bone Regeneration
/ drug effects
Chitosan
/ administration & dosage
Disease Models, Animal
Drug Carriers
/ administration & dosage
Drug Compounding
/ methods
Drug Evaluation, Preclinical
/ methods
Drug Implants
/ administration & dosage
Glass
/ chemistry
Male
Nanoparticles
/ administration & dosage
Raloxifene Hydrochloride
/ administration & dosage
Rats
Rats, Sprague-Dawley
Tibia
/ drug effects
Treatment Outcome
Bioactive glass
Bone injury
Chitosan
In-situ forming implant
Raloxifene hydrochloride
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
30 Apr 2020
30 Apr 2020
Historique:
received:
25
11
2019
revised:
01
03
2020
accepted:
07
03
2020
pubmed:
14
3
2020
medline:
16
1
2021
entrez:
14
3
2020
Statut:
ppublish
Résumé
In-situ forming implants receive great attention for repairing serious bone injuries. The aim of the present study was to prepare novel chitosan in-situ forming implants (CIFI) loaded with bioactive glass nanoparticles and/or raloxifene hydrochloride (RLX). Incorporating raloxifene hydrochloride (RLX) as a selective estrogen receptor modulator was essential to make use of its anti-resorptive properties. The prepared formulae were tested for their in-vitro gelation time, drug release, injectability, rheological properties, erosion rate and morphological properties. Results revealed that the formulation composed of 1% (w/v) chitosan with 2% (w/v) NaHCO
Identifiants
pubmed: 32165229
pii: S0378-5173(20)30197-6
doi: 10.1016/j.ijpharm.2020.119213
pii:
doi:
Substances chimiques
13-93 bioactive glass
0
Bone Density Conservation Agents
0
Drug Carriers
0
Drug Implants
0
Raloxifene Hydrochloride
4F86W47BR6
Chitosan
9012-76-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119213Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.