Terminally Differentiated Effector Memory CD8


Journal

Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836

Informations de publication

Date de publication:
04 2020
Historique:
received: 27 08 2019
accepted: 16 01 2020
pubmed: 14 3 2020
medline: 11 11 2020
entrez: 14 3 2020
Statut: ppublish

Résumé

Identifying biomarkers to predict kidney transplant failure and to define new therapeutic targets requires more comprehensive understanding of the immune response to chronic allogeneic stimulation. We investigated the frequency and function of CD8 Increased frequency of circulating TEMRA CD8 At 1 year post-transplant, the composition of memory CD8

Sections du résumé

BACKGROUND
Identifying biomarkers to predict kidney transplant failure and to define new therapeutic targets requires more comprehensive understanding of the immune response to chronic allogeneic stimulation.
METHODS
We investigated the frequency and function of CD8
RESULTS
Increased frequency of circulating TEMRA CD8
CONCLUSIONS
At 1 year post-transplant, the composition of memory CD8

Identifiants

pubmed: 32165419
pii: ASN.2019080847
doi: 10.1681/ASN.2019080847
pmc: PMC7191929
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

876-891

Informations de copyright

Copyright © 2020 by the American Society of Nephrology.

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Auteurs

Lola Jacquemont (L)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Gaëlle Tilly (G)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Michelle Yap (M)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Tra-My Doan-Ngoc (TM)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Richard Danger (R)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Pierrick Guérif (P)

CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Florent Delbos (F)

Etablissement Français du Sang, Nantes, France; and.

Bernard Martinet (B)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Magali Giral (M)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Yohann Foucher (Y)

INSERM, Université de Nantes, methodS in Patient-centered outcomes and HEalth ResEarch (SPHERE), UMR1246, Nantes, France.

Sophie Brouard (S)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

Nicolas Degauque (N)

Université de Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, Nantes, France; nicolas.degauque@univ-nantes.fr.
CHU Nantes, Université de Nantes, ITUN, Nantes, France.

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