Are Adverse Events Attributed to Essure Associated With Nickel Sensitization?
Adult
Allergens
/ adverse effects
Arthralgia
/ etiology
Device Removal
Dyspareunia
/ etiology
Eczema
/ etiology
Fallopian Tubes
/ pathology
Fatigue
/ etiology
Female
Headache
/ etiology
Humans
Hypersensitivity, Delayed
/ diagnosis
Hysteroscopy
Laparoscopy
Metrorrhagia
/ etiology
Middle Aged
Nickel
/ adverse effects
Oximes
Patch Tests
Pelvic Pain
/ etiology
Prostheses and Implants
/ adverse effects
Salpingectomy
Skin Diseases
/ etiology
Sterilization, Tubal
/ instrumentation
Journal
Dermatitis : contact, atopic, occupational, drug
ISSN: 2162-5220
Titre abrégé: Dermatitis
Pays: United States
ID NLM: 101207335
Informations de publication
Date de publication:
Historique:
entrez:
14
3
2020
pubmed:
14
3
2020
medline:
6
1
2021
Statut:
ppublish
Résumé
Essure is an effective method for hysteroscopic sterilization. Reports of adverse effects, the underlying mechanisms of which are unknown, have increased in recent years. The aim of the study was to determine whether there is a relationship between adverse events attributed to Essure and nickel sensitization. Patients presenting alleged adverse reactions to Essure were referred for nickel patch testing before removal. Data regarding medical history of nickel sensitization and symptoms attributed to Essure were collected. Dimethylglyoxime spot tests were performed on the explanted Essure. There was a follow-up at 3 months to evaluate whether there is improvement of the symptoms after Essure removal. Nickel sensitization via the classic delayed hypersensitivity pathway did not seem to be responsible for adverse events attributed to Essure. Among systemic symptoms reported, extracutaneous symptoms had the highest prevalence. Systemic contact dermatitis to nickel could not be ruled out in one case.
Sections du résumé
BACKGROUND
BACKGROUND
Essure is an effective method for hysteroscopic sterilization. Reports of adverse effects, the underlying mechanisms of which are unknown, have increased in recent years.
OBJECTIVE
OBJECTIVE
The aim of the study was to determine whether there is a relationship between adverse events attributed to Essure and nickel sensitization.
METHODS
METHODS
Patients presenting alleged adverse reactions to Essure were referred for nickel patch testing before removal. Data regarding medical history of nickel sensitization and symptoms attributed to Essure were collected. Dimethylglyoxime spot tests were performed on the explanted Essure. There was a follow-up at 3 months to evaluate whether there is improvement of the symptoms after Essure removal.
CONCLUSIONS
CONCLUSIONS
Nickel sensitization via the classic delayed hypersensitivity pathway did not seem to be responsible for adverse events attributed to Essure. Among systemic symptoms reported, extracutaneous symptoms had the highest prevalence. Systemic contact dermatitis to nickel could not be ruled out in one case.
Identifiants
pubmed: 32168143
doi: 10.1097/DER.0000000000000489
pii: 01206501-202003000-00006
doi:
Substances chimiques
Allergens
0
Oximes
0
dimethylglyoxime
2971MFT1KY
nickel sulfate
4FLT4T3WUN
Nickel
7OV03QG267
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM