Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water.
Cholesterol
Perfluoroalkyl substances (PFAS)
Perfluorohexane sulfonic acid (PFHxS)
Perfluorooctane sulfonic acid (PFOS)
Perfluorooctanoic acid (PFOA)
Serum lipids
Journal
Environmental health : a global access science source
ISSN: 1476-069X
Titre abrégé: Environ Health
Pays: England
ID NLM: 101147645
Informations de publication
Date de publication:
14 03 2020
14 03 2020
Historique:
received:
29
11
2019
accepted:
04
03
2020
entrez:
15
3
2020
pubmed:
15
3
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Exposures to perfluoroalkyl substances (PFAS) have shown positive associations with serum lipids in previous studies. While many studies on lipids investigated associations with perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), there are only a few studies regarding other PFAS, such as perfluorohexane sulfonic acid (PFHxS). The purpose of the current study is to investigate if associations with serum lipids were present, not only for serum PFOS and PFOA, but also for PFHxS, and if the associations with PFAS remained also in a comparison based only on residency in areas with contrasting exposure to PFAS. 1945 adults aged 20-60 were included from Ronneby, Sweden, a municipality where one out of two waterworks had been heavily contaminated from aqueous fire-fighting foams, and from a nearby control area. The exposure was categorized based on either been living in areas with contrasting PFAS exposure or based on the actual serum PFAS measurements. Regression analyses of serum lipids were fitted against serum PFAS levels, percentile groups, smooth splines and between exposed and reference areas, adjusting for age, sex and BMI. Drinking water contamination caused high serum levels of PFOS (median 157 ng/ml) and PFHxS (median 136 ng/ml) and PFOA (median 8.6 ng/ml). These serum PFAS levels in the exposed groups were 5 to 100-fold higher than in the controls. In this population with mixed PFAS exposure, predominantly PFOS and PFHxS, PFAS exposure were positively associated with serum lipids. This was observed both when quantifying exposure as contrast between exposed and controls, and in terms of serum PFAS. Due to high correlations between each PFAS, we cannot separate them. In conclusion, the present study provides further evidence of a causal association between PFAS and serum lipids, especially for PFHxS.
Sections du résumé
BACKGROUND
Exposures to perfluoroalkyl substances (PFAS) have shown positive associations with serum lipids in previous studies. While many studies on lipids investigated associations with perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), there are only a few studies regarding other PFAS, such as perfluorohexane sulfonic acid (PFHxS). The purpose of the current study is to investigate if associations with serum lipids were present, not only for serum PFOS and PFOA, but also for PFHxS, and if the associations with PFAS remained also in a comparison based only on residency in areas with contrasting exposure to PFAS.
METHODS
1945 adults aged 20-60 were included from Ronneby, Sweden, a municipality where one out of two waterworks had been heavily contaminated from aqueous fire-fighting foams, and from a nearby control area. The exposure was categorized based on either been living in areas with contrasting PFAS exposure or based on the actual serum PFAS measurements. Regression analyses of serum lipids were fitted against serum PFAS levels, percentile groups, smooth splines and between exposed and reference areas, adjusting for age, sex and BMI.
RESULTS
Drinking water contamination caused high serum levels of PFOS (median 157 ng/ml) and PFHxS (median 136 ng/ml) and PFOA (median 8.6 ng/ml). These serum PFAS levels in the exposed groups were 5 to 100-fold higher than in the controls. In this population with mixed PFAS exposure, predominantly PFOS and PFHxS, PFAS exposure were positively associated with serum lipids. This was observed both when quantifying exposure as contrast between exposed and controls, and in terms of serum PFAS. Due to high correlations between each PFAS, we cannot separate them.
CONCLUSIONS
In conclusion, the present study provides further evidence of a causal association between PFAS and serum lipids, especially for PFHxS.
Identifiants
pubmed: 32169067
doi: 10.1186/s12940-020-00588-9
pii: 10.1186/s12940-020-00588-9
pmc: PMC7071576
doi:
Substances chimiques
Alkanesulfonic Acids
0
Caprylates
0
Drinking Water
0
Fluorocarbons
0
Lipids
0
Sulfonic Acids
0
Water Pollutants, Chemical
0
perfluorohexanesulfonic acid
355-46-4
perfluorooctanoic acid
947VD76D3L
perfluorooctane sulfonic acid
9H2MAI21CL
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
33Subventions
Organisme : Svenska Forskningsrådet Formas
ID : 216-2014-1709
Pays : International
Organisme : Forskningsrådet för Arbetsliv och Socialvetenskap (SE)
ID : 2015-732
Pays : International
Références
Circulation. 1998 May 12;97(18):1837-47
pubmed: 9603539
Arch Pediatr Adolesc Med. 2010 Sep;164(9):860-9
pubmed: 20819969
Lancet. 2007 Dec 1;370(9602):1829-39
pubmed: 18061058
Environ Sci Technol. 2010 Sep 15;44(18):7123-9
pubmed: 20722423
Epidemiology. 2013 Jul;24(4):569-76
pubmed: 23685825
Environ Health Perspect. 2010 Feb;118(2):197-202
pubmed: 20123614
Am J Epidemiol. 2009 Nov 15;170(10):1268-78
pubmed: 19846564
Environ Int. 2013 Jul;57-58:2-10
pubmed: 23624243
Environ Int. 2014 Jan;62:104-12
pubmed: 24189199
Environ Res. 2015 Nov;143(Pt A):33-8
pubmed: 26432473
Sci Total Environ. 2015 Apr 15;512-513:364-370
pubmed: 25638651
Environ Res. 2010 Oct;110(7):710-7
pubmed: 20696425
Environ Int. 2019 Aug;129:343-353
pubmed: 31150976
Anal Bioanal Chem. 2019 Nov 23;:
pubmed: 31760452
Occup Environ Med. 2018 Jan;75(1):46-51
pubmed: 29133598
PLoS One. 2013;8(2):e56969
pubmed: 23441227
Environ Res. 2013 Feb;121:95-103
pubmed: 23266098
Chemosphere. 2012 Sep;88(11):1269-75
pubmed: 22494529
Environ Int. 2011 May;37(4):687-93
pubmed: 21334069
Environ Health Perspect. 2014 Dec;122(12):1299-305
pubmed: 25260175
Environ Sci Technol. 2009 Aug 1;43(15):5565-75
pubmed: 19731646