Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability.

Animals Cattle Enzyme Inhibitors / chemistry Humans Peptides / chemistry Proteolysis Serine Endopeptidases / metabolism
Amphibian-derived peptidic inhibitors Matriptase-1 Molecular docking

Journal

Biochimie
ISSN: 1638-6183
Titre abrégé: Biochimie
Pays: France
ID NLM: 1264604

Informations de publication

Date de publication:
Historique:
received: 30 09 2019
accepted: 04 03 2020
pubmed: 15 3 2020
medline: 15 12 2020
entrez: 15 3 2020
Statut: ppublish

Résumé

A gradual truncation of the primary structure of frog skin-derived Huia versabilis Bowman-Birk peptidic inhibitor (HV-BBI) resulted in 18-times stronger inhibitor of matriptase-1 (peptide 6, K

Identifiants

DOI: 10.1016/j.biochi.2020.03.006 PMID: 32169666
pubmed: 32169666
pii: S0300-9084(20)30051-1
doi: 10.1016/j.biochi.2020.03.006
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
HV-BBI peptide, Huia versabilis 0
Peptides 0
Serine Endopeptidases EC 3.4.21.-
matriptase EC 3.4.21.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

178-186

Informations de copyright

Copyright © 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

Auteurs

Agata Gitlin-Domagalska (A)

Faculty of Chemistry, Department of Molecular Biochemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Dawid Dębowski (D)

Faculty of Chemistry, Department of Molecular Biochemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland. Electronic address: dawid.debowski@ug.edu.pl.

Katarzyna Gucwa (K)

Faculty of Chemistry, Department of Molecular Biochemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Dominika Starego (D)

Faculty of Chemistry, Department of Molecular Biochemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Natalia Ptaszyńska (N)

Faculty of Chemistry, Department of Molecular Biochemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Adam Sieradzan (A)

Faculty of Chemistry, Department of Theoretical Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Agnieszka Karczyńska (A)

Faculty of Chemistry, Department of Theoretical Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Sergey A Samsonov (SA)

Faculty of Chemistry, Department of Theoretical Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Martin Mangold (M)

Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.

Michael Gütschow (M)

Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.

Anna Łęgowska (A)

Faculty of Chemistry, Department of Molecular Biochemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

Krzysztof Rolka (K)

Faculty of Chemistry, Department of Molecular Biochemistry, University of Gdańsk, Wita Stwosza 63, 80-308, Gdansk, Poland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Truncation of Huia versabilis Bowman-Birk...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Truncation of Huia versabilis Bowman-Birk...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Truncation of Huia versabilis Bowman-Birk...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Truncation of Huia versabilis Bowman-Birk...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Truncation of Huia versabilis Bowman-Birk...
questionsmedicales.fr › Métabolisme › Protéolyse › Truncation of Huia versabilis Bowman-Birk...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Truncation of Huia versabilis Bowman-Birk...