Moving Toward Multicenter Therapeutic Trials in Amyotrophic Lateral Sclerosis: Feasibility of Data Pooling Using Different Translocator Protein PET Radioligands.
Acetamides
/ pharmacokinetics
Adult
Aged
Amyotrophic Lateral Sclerosis
/ diagnostic imaging
Carbon Radioisotopes
/ pharmacokinetics
Clinical Trials as Topic
Feasibility Studies
Female
Fluorine Radioisotopes
/ pharmacokinetics
Humans
Male
Middle Aged
Positron-Emission Tomography
/ methods
Pyrazoles
/ pharmacokinetics
Pyridines
/ pharmacokinetics
Pyrimidines
/ pharmacokinetics
Receptors, GABA
/ metabolism
11C-PBR28
18F-DPA714
amyotrophic lateral sclerosis
multicenter
translocator protein
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
15
12
2019
accepted:
05
03
2020
pubmed:
15
3
2020
medline:
10
3
2021
entrez:
15
3
2020
Statut:
ppublish
Résumé
Neuroinflammation has been implicated in amyotrophic lateral sclerosis (ALS) and can be visualized using translocator protein (TSPO) radioligands. To become a reliable pharmacodynamic biomarker for ALS multicenter trials, TSPO radioligands have some challenges to overcome. We aimed to investigate whether multicenter data pooling of different TSPO tracers (
Identifiants
pubmed: 32169920
pii: jnumed.119.241059
doi: 10.2967/jnumed.119.241059
pmc: PMC9364895
doi:
Substances chimiques
Acetamides
0
Carbon Radioisotopes
0
Fluorine Radioisotopes
0
N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamide
0
N-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide
0
Pyrazoles
0
Pyridines
0
Pyrimidines
0
Receptors, GABA
0
TSPO protein, human
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1621-1627Subventions
Organisme : NIH HHS
ID : S10 OD023517
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS083715
Pays : United States
Informations de copyright
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.
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