Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen.

Animals Autoantigens / immunology Autoimmunity / immunology Cross-Priming / immunology Dendritic Cells / immunology Histocompatibility Antigens Class II / immunology Mice Mice, Inbred C57BL

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
13 03 2020
Historique:
received: 12 11 2019
accepted: 18 02 2020
entrez: 15 3 2020
pubmed: 15 3 2020
medline: 1 1 2021
Statut: ppublish

Résumé

Conventional dendritic cells expressing the XCR1 chemokine receptor (cDC1s) excel at cross-presentation. Here, we developed and used a mouse model in which a Cre recombinase is expressed under the control of the

Identifiants

DOI: 10.1126/sciimmunol.aba1896 PMID: 32169954
pubmed: 32169954
pii: 5/45/eaba1896
doi: 10.1126/sciimmunol.aba1896
pii:
doi:

Substances chimiques

Autoantigens 0
Histocompatibility Antigens Class II 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Christian Wohn (C)

Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.
ORCID: 0000-0002-8276-4658

Valentin Le Guen (V)

Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.

Odessa Voluzan (O)

Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.

Frédéric Fiore (F)

Centre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.

Sandrine Henri (S)

Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France. bernardm@ciml.univ-mrs.fr henri@ciml.univ-mrs.fr.
ORCID: 0000-0002-8980-9193

Bernard Malissen (B)

Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France. bernardm@ciml.univ-mrs.fr henri@ciml.univ-mrs.fr.
Centre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS, 13288 Marseille, France.
ORCID: 0000-0003-1340-9342

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Absence of MHC class II on cDC1 dendritic...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Autoantigènes › Absence of MHC class II on cDC1 dendritic...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Absence of MHC class II on cDC1 dendritic...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Cross-priming › Absence of MHC class II on cDC1 dendritic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Absence of MHC class II on cDC1 dendritic...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe II › Absence of MHC class II on cDC1 dendritic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Absence of MHC class II on cDC1 dendritic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Absence of MHC class II on cDC1 dendritic...