Randomised trial of azithromycin to eradicate
Anti-Bacterial Agents
/ administration & dosage
Azithromycin
/ administration & dosage
Bronchopulmonary Dysplasia
/ etiology
Double-Blind Method
Drug Administration Schedule
Female
Gestational Age
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature, Diseases
/ drug therapy
Intensive Care Units, Neonatal
Intention to Treat Analysis
Male
Prospective Studies
Respiratory Tract Infections
/ complications
Risk Factors
Ureaplasma Infections
/ complications
bronchopulmonary dysplasia
neonatology
prematurity
ureaplasma parvum
ureaplasma urealyticum
Journal
Archives of disease in childhood. Fetal and neonatal edition
ISSN: 1468-2052
Titre abrégé: Arch Dis Child Fetal Neonatal Ed
Pays: England
ID NLM: 9501297
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
20
08
2019
revised:
26
01
2020
accepted:
25
02
2020
pubmed:
15
3
2020
medline:
4
11
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
To test whether azithromycin eradicates Prospective, phase IIb randomised, double-blind, placebo-controlled trial. Seven level III-IV US, academic, neonatal intensive care units (NICUs). Infants 24 Intravenous azithromycin 20 mg/kg or an equal volume of D5W (placebo) every 24 hours for 3 days. The primary efficacy outcome was One hundred and twenty-one randomised participants (azithromycin: n=60; placebo: n=61) were included in the intent-to-treat analysis (mean gestational age 26.2±1.4 weeks). Forty-four of 121 participants (36%) were A 3-day azithromycin regimen effectively eradicated respiratory tract NCT01778634.
Identifiants
pubmed: 32170033
pii: archdischild-2019-318122
doi: 10.1136/archdischild-2019-318122
pmc: PMC7592356
doi:
Substances chimiques
Anti-Bacterial Agents
0
Azithromycin
83905-01-5
Banques de données
ClinicalTrials.gov
['NCT01778634']
Types de publication
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
615-622Subventions
Organisme : NICHD NIH HHS
ID : R01 HD067126
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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