Combined reduction in the expression of MCL-1 and BCL-2 reduces organismal size in mice.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
13 03 2020
13 03 2020
Historique:
received:
11
12
2019
accepted:
19
02
2020
revised:
19
02
2020
entrez:
15
3
2020
pubmed:
15
3
2020
medline:
14
4
2021
Statut:
epublish
Résumé
The intrinsic apoptotic pathway is controlled by the BCL-2 family of proteins, which exhibit either a pro-death or pro-survival function. Gene knockout studies revealed that different pro-survival BCL-2 proteins are critical for the survival of distinct cell types, although overlapping functions amongst such proteins have also been identified. In the process of studying mice lacking single alleles of Mcl-1 (Mcl-1
Identifiants
pubmed: 32170090
doi: 10.1038/s41419-020-2376-5
pii: 10.1038/s41419-020-2376-5
pmc: PMC7070015
doi:
Substances chimiques
Mcl1 protein, mouse
0
Myeloid Cell Leukemia Sequence 1 Protein
0
Proto-Oncogene Proteins c-bcl-2
0
Bcl2 protein, mouse
114100-40-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
185Références
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