Centrosomes: The good and the bad for brain development.
brain development and brain growth disorders
centrosomes
mitotic errors
mitotic spindle assembly and disorganisation
neural stem cell division and fitness
Journal
Biology of the cell
ISSN: 1768-322X
Titre abrégé: Biol Cell
Pays: England
ID NLM: 8108529
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
30
10
2019
revised:
25
02
2020
accepted:
01
03
2020
pubmed:
15
3
2020
medline:
30
12
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
Centrosomes nucleate and organise the microtubule cytoskeleton in animal cells. These membraneless organelles are key structures for tissue organisation, polarity and growth. Centrosome dysfunction, defined as deviation in centrosome numbers and/or structural integrity, has major impact on brain size and functionality, as compared with other tissues of the organism. In this review, we discuss the contribution of centrosomes to brain growth during development. We discuss in particular the impact of centrosome dysfunction in Drosophila and mammalian neural stem cell division and fitness, which ultimately underlie brain growth defects.
Identifiants
pubmed: 32170757
doi: 10.1111/boc.201900090
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
153-172Informations de copyright
© 2020 Société Française des Microscopies and Société de Biologie Cellulaire de France. Published by John Wiley & Sons Ltd.
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