Keratinocyte: A trigger or an executor of psoriasis?
cytokines/chemokines
inflammatory response
mantainence
onset
relapse
Journal
Journal of leukocyte biology
ISSN: 1938-3673
Titre abrégé: J Leukoc Biol
Pays: England
ID NLM: 8405628
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
08
12
2019
revised:
21
01
2020
accepted:
21
02
2020
pubmed:
15
3
2020
medline:
15
12
2020
entrez:
15
3
2020
Statut:
ppublish
Résumé
Psoriasis is a common chronic inflammatory skin disease characterized by abnormal proliferation/differentiation of keratinocytes and excessive immune cell infiltration in the dermis and epidermis. Over the past 2 decades, immune cells have been considered as the main driver of psoriasis because the neutralizing antibodies targeting the IL-23/IL-17 axis that regulates cross-talk between dendritic cells and T cells achieve tremendous success in the treatment of psoriasis. However, whether keratinocyte would be a driver of psoriasis or just an executor in response to immune cells is still under debate. In this review, we focus on the recent advances in the identification of keratinocyte as a trigger of psoriasis, summarize on the role of keratinocytes in self-perpetuating loop to maintain inflammation in psoriasis, and then discuss the possible roles of keratinocytes in the relapse of psoriasis.
Identifiants
pubmed: 32170886
doi: 10.1002/JLB.5MR0120-439R
doi:
Substances chimiques
Cytokines
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-491Informations de copyright
©2020 Society for Leukocyte Biology.
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