The Angiopoietin-Tie2 Pathway in Critical Illness.

Acute Kidney Injury / enzymology Angiopoietin-1 / metabolism Angiopoietin-2 / metabolism Animals Critical Illness Disseminated Intravascular Coagulation / enzymology Endothelium, Vascular / metabolism Homeostasis / physiology Humans Receptor, TIE-2 / metabolism Respiratory Distress Syndrome / enzymology Sepsis / enzymology Signal Transduction
ARDS Angiopoietin Coagulation Sepsis Tie2 VE-PTP Vascular leakage

Journal

Critical care clinics
ISSN: 1557-8232
Titre abrégé: Crit Care Clin
Pays: United States
ID NLM: 8507720

Informations de publication

Date de publication:
Apr 2020
Historique:
entrez: 17 3 2020
pubmed: 17 3 2020
medline: 29 12 2020
Statut: ppublish

Résumé

Lethal features of sepsis and acute respiratory distress syndrome (ARDS) relate to the health of small blood vessels. For example, alveolar infiltration with proteinaceous fluid is often driven by breach of the microvascular barrier. Spontaneous thrombus formation within inflamed microvessels exacerbates organ ischemia, and in its final stages, erupts into overt disseminated intravascular coagulation. Disruption of an endothelial signaling axis, the Angiopoietin-Tie2 pathway, may mediate the abrupt transition from microvascular integrity to pathologic disruption. This review summarizes preclinical and clinical results that implicate the Tie2 pathway as a promising target to restore microvascular health in sepsis and ARDS.

Identifiants

DOI: 10.1016/j.ccc.2019.12.003 PMID: 32172809 PMC: PMC8843037
pubmed: 32172809
pii: S0749-0704(19)30098-3
doi: 10.1016/j.ccc.2019.12.003
pmc: PMC8843037
mid: NIHMS1569472
pii:
doi:

Substances chimiques

Angiopoietin-1 0
Angiopoietin-2 0
Receptor, TIE-2 EC 2.7.10.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

201-216

Subventions

Organisme : NHLBI NIH HHS
ID : R35 HL139424
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure S.M. Parikh is a member of the Scientific Advisory Board for Aerpio.

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Auteurs

Kelsey D Sack (KD)

Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RN330C, Boston, MA 02215, USA.

John A Kellum (JA)

Department of Critical Care Medicine, CRISMA Center, University of Pittsburgh, University of Pittsburgh, School of Medicine, 3347 Forbes Avenue, Suite 220, Room 202, Pittsburgh, PA 15213, USA.

Samir M Parikh (SM)

Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RN330C, Boston, MA 02215, USA. Electronic address: sparikh1@bidmc.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Angiopoïétines › Angiopoïétine-1 › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines angiogéniques › Angiopoïétines › Angiopoïétine-2 › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Eucaryotes › Animaux › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie grave › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Thrombophilie › Coagulation intravasculaire disséminée › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › Récepteurs TIE › Récepteur TIE-2 › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › The Angiopoietin-Tie2 Pathway in Critical Illness.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The Angiopoietin-Tie2 Pathway in Critical Illness.