Coagulation Disorders in Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome.
Coagulation
Fibrinolysis
Hemophagocytic lymphohistiocytosis
Hemorrhage
Journal
Critical care clinics
ISSN: 1557-8232
Titre abrégé: Crit Care Clin
Pays: United States
ID NLM: 8507720
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
29
12
2020
Statut:
ppublish
Résumé
Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe condition that can lead patients to the intensive care unit. HLH diagnosis may be challenging, as it relies on sets of aspecific criteria. Several organ dysfunctions have been described during HLH, including hemostasis impairment found in more than half of the patients. The most frequently reported anomaly is a decrease in the fibrinogen level, which has been associated with higher mortality rates. Coagulation impairment study in patients with HLH represents an interesting field of research, as little is known about the mechanism leading to hypofibrinogenemia.
Identifiants
pubmed: 32172822
pii: S0749-0704(19)30099-5
doi: 10.1016/j.ccc.2019.12.004
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
415-426Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure The authors have nothing to disclose.