An injectable recombinant human milk fat globule-epidermal growth factor 8-loaded copolymer system for spinal cord injury reduces inflammation through NF-κB and neuronal cell death.
Animals
Antigens, Surface
/ administration & dosage
Cell Death
/ drug effects
Cytokines
/ metabolism
Disease Models, Animal
Drug Delivery Systems
/ methods
Female
Humans
Hydrogels
/ administration & dosage
Inflammation
/ drug therapy
Injections
Milk Proteins
/ administration & dosage
Myelin Sheath
/ metabolism
NF-kappa B
/ metabolism
Nerve Regeneration
/ drug effects
PC12 Cells
Polyethylene Glycols
/ administration & dosage
Polyglactin 910
/ administration & dosage
Rats
Rats, Sprague-Dawley
Signal Transduction
/ drug effects
Spinal Cord Injuries
/ drug therapy
Treatment Outcome
inflammation
milk fat globule–epidermal growth factor 8
poly- (DL-lactic acid co-glycolic acid)–polyethylene glycol–poly- (DL-lactic acid co-glycolic acid) copolymer
spinal cord injury
Journal
Cytotherapy
ISSN: 1477-2566
Titre abrégé: Cytotherapy
Pays: England
ID NLM: 100895309
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
21
11
2019
revised:
19
01
2020
accepted:
30
01
2020
pubmed:
17
3
2020
medline:
28
10
2020
entrez:
17
3
2020
Statut:
ppublish
Résumé
Spinal cord injury (SCI) is a common disease and a major cause of paralysis, carrying much burden around the world. Despite the progress made with growth factors therapy, the response rate of acute SCI treatment still remains unsatisfactory, due largely to complex and severe inflammatory reactions. Herein, we prepare a MFG-E8-loaded copolymer system-based anti-inflammation therapy for SCI treatment. It is shown that the MFG-E8-loaded copolymer system can decrease pro-inflammatory cytokine expression and neuron death. In a rat model of crush-caused SCI, the copolymer system shows significant therapeutic efficacy by ameliorating inflammation, decreasing fibrotic scar, promoting myelin regeneration and suppressing overall SCI severity.
Identifiants
pubmed: 32173261
pii: S1465-3249(20)30036-0
doi: 10.1016/j.jcyt.2020.01.016
pii:
doi:
Substances chimiques
Antigens, Surface
0
Cytokines
0
Hydrogels
0
MFGE8 protein, human
0
Milk Proteins
0
NF-kappa B
0
poly(lactic-co-glycolic acid)-polyethylene glycol-poly(lactic-co-glycolic acid)
0
Polyglactin 910
34346-01-5
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
193-203Informations de copyright
Copyright © 2020 International Society for Cell and Gene Therapy. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no commercial, proprietary, or financial interest in the products or companies described in this article.