Preoperative prealbumin levels on admission as an independent predictive factor in patients with gastric cancer.
Adult
Age Factors
Aged
Aged, 80 and over
Biomarkers, Tumor
/ blood
Chi-Square Distribution
China
Cohort Studies
Disease-Free Survival
Female
Gastrectomy
/ methods
Hospitals, University
Humans
Male
Middle Aged
Prealbumin
/ metabolism
Predictive Value of Tests
Preoperative Care
/ methods
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Statistics, Nonparametric
Stomach Neoplasms
/ mortality
Survival Analysis
Treatment Outcome
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
17
3
2020
pubmed:
17
3
2020
medline:
27
3
2020
Statut:
ppublish
Résumé
To explore the role of preoperative prealbumin levels in predicting the prognosis of patients with gastric cancer. A total of 989 gastric cancer patients in the Affiliated Tumour Hospital of Harbin Medical University who underwent gastrectomy were included in this retrospective study. The preoperative prealbumin level, clinicopathological data, and follow-up data were recorded. According to the maximum chi-square survival correlation value, the survival of patients with low preoperative prealbumin (<140 mg/L) and high preoperative prealbumin (≥140 mg/L) were compared using the log-rank test and the Cox proportional hazard regression model. Based on the best cut-off value of 140 mg/L, we divided the patients into the lower prealbumin group (<140 mg/L) and the higher prealbumin group (≥140 mg/L). Compared with the higher prealbumin group, the lower prealbumin group were older and had larger tumor volumes, lower hemoglobin (Hb) levels, and more upper gastric cancer tumors. The univariate analysis showed that prealbumin and other clinicopathological factors, including age, hemoglobin, tumor size, macroscopic type, cell differentiation, liver metastasis, operation type, N stage, and T stage, were significant prognostic factors. The multivariable analysis showed that age, prealbumin, macroscopic type, location, T stage, and N stage were independent prognostic factors. The preoperative prealbumin level was an independent prognostic factor for patients with gastric cancer. The preoperative prealbumin level can be used to predict the prognosis of patients with gastric cancer and guide clinical practice.
Sections du résumé
BACKGROUND
BACKGROUND
To explore the role of preoperative prealbumin levels in predicting the prognosis of patients with gastric cancer.
METHODS
METHODS
A total of 989 gastric cancer patients in the Affiliated Tumour Hospital of Harbin Medical University who underwent gastrectomy were included in this retrospective study. The preoperative prealbumin level, clinicopathological data, and follow-up data were recorded. According to the maximum chi-square survival correlation value, the survival of patients with low preoperative prealbumin (<140 mg/L) and high preoperative prealbumin (≥140 mg/L) were compared using the log-rank test and the Cox proportional hazard regression model.
RESULTS
RESULTS
Based on the best cut-off value of 140 mg/L, we divided the patients into the lower prealbumin group (<140 mg/L) and the higher prealbumin group (≥140 mg/L). Compared with the higher prealbumin group, the lower prealbumin group were older and had larger tumor volumes, lower hemoglobin (Hb) levels, and more upper gastric cancer tumors. The univariate analysis showed that prealbumin and other clinicopathological factors, including age, hemoglobin, tumor size, macroscopic type, cell differentiation, liver metastasis, operation type, N stage, and T stage, were significant prognostic factors. The multivariable analysis showed that age, prealbumin, macroscopic type, location, T stage, and N stage were independent prognostic factors.
CONCLUSIONS
CONCLUSIONS
The preoperative prealbumin level was an independent prognostic factor for patients with gastric cancer. The preoperative prealbumin level can be used to predict the prognosis of patients with gastric cancer and guide clinical practice.
Identifiants
pubmed: 32176046
doi: 10.1097/MD.0000000000019196
pii: 00005792-202003130-00023
pmc: PMC7440214
doi:
Substances chimiques
Biomarkers, Tumor
0
Prealbumin
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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