ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations.
caries
dental fluorosis
enamelin
genetic variation
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
12 03 2020
12 03 2020
Historique:
received:
13
02
2020
revised:
06
03
2020
accepted:
08
03
2020
entrez:
18
3
2020
pubmed:
18
3
2020
medline:
22
9
2020
Statut:
epublish
Résumé
The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher's exact and Kruskal-Wallis tests. Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group ( The ENAM gene showed an association in the population exposed to different concentrations of fluoride.
Identifiants
pubmed: 32178265
pii: ijerph17061832
doi: 10.3390/ijerph17061832
pmc: PMC7143052
pii:
doi:
Substances chimiques
ENAM protein, human
0
Extracellular Matrix Proteins
0
Fluorides
Q80VPU408O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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