Infiltrating Mast Cell-Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype.
Animals
Breast Neoplasms
/ genetics
Cell Communication
/ physiology
Cell Growth Processes
/ physiology
Cell Line, Tumor
ErbB Receptors
/ metabolism
Female
Humans
Male
Mammary Neoplasms, Experimental
/ genetics
Mast Cells
/ pathology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Neoplasm Metastasis
Proto-Oncogene Proteins c-met
/ metabolism
Receptor, ErbB-2
/ metabolism
Receptors, Estrogen
/ metabolism
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
14
11
2019
revised:
04
02
2020
accepted:
11
03
2020
pubmed:
18
3
2020
medline:
12
11
2020
entrez:
18
3
2020
Statut:
ppublish
Résumé
Tumor growth and development is determined by both cancer cell-autonomous and microenvironmental mechanisms, including the contribution of infiltrating immune cells. Because the role of mast cells (MC) in this process is poorly characterized and even controversial, we investigated their part in breast cancer. Crossing C57BL/6 MMTV-PyMT mice, which spontaneously develop mammary carcinomas, with MC-deficient C57BL/6-Kit
Identifiants
pubmed: 32179512
pii: 0008-5472.CAN-19-3596
doi: 10.1158/0008-5472.CAN-19-3596
doi:
Substances chimiques
Receptors, Estrogen
0
ErbB Receptors
EC 2.7.10.1
Proto-Oncogene Proteins c-met
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2311-2324Informations de copyright
©2020 American Association for Cancer Research.