Nicotine Content from Cigarettes Submerged in Soda.
Journal
Journal of medical toxicology : official journal of the American College of Medical Toxicology
ISSN: 1937-6995
Titre abrégé: J Med Toxicol
Pays: United States
ID NLM: 101284598
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
01
10
2019
accepted:
21
02
2020
revised:
18
02
2020
pubmed:
18
3
2020
medline:
27
7
2021
entrez:
18
3
2020
Statut:
ppublish
Résumé
Cigarettes and other tobacco products may be extinguished by submersion in liquids in beverage cans or bottles. Cases of nicotine poisoning in children have been reported following ingestion of such liquids. The aim of this study is to analyze the variability of nicotine concentrations with respect to number of cigarettes immersed and the duration of immersion in a soda can METHODS: One unsmoked cigarette was immersed in a cola containing soda can. Three separate samples of the mixture were obtained at different intervals of time post immersion up to 1 week. At the same time, a set of four cola cans were immersed with an increasing number of unsmoked cigarettes and samples obtained. All the samples were then analyzed for nicotine concentrations using liquid chromatography-mass spectrometry. The mean concentration of nicotine measured over the course of 6 hours from one full cigarette in 55 ml of a cola beverage was 0.48 mg/ml. Nicotine concentrations steadily increased in the first 6 hours following submersion, after which, the levels plateaued (r = 0.530, n = 18, p = 0.024). There was a strong positive correlation between nicotine concentrations and the number of cigarettes (r = 0.967, n = 12, p = 3e-7). The mean concentration of nicotine measured over the course of 6 hours from one immersed cigarette can be potentially toxic especially to children. Nicotine concentrations are positively correlated with the number of cigarettes and time of immersion.
Identifiants
pubmed: 32180139
doi: 10.1007/s13181-020-00766-8
pii: 10.1007/s13181-020-00766-8
pmc: PMC7554291
doi:
Substances chimiques
Nicotinic Agonists
0
Nicotine
6M3C89ZY6R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
452-457Références
Yamamoto H, Takayasu T, Ishida Y, Nosaka M, Hata S, Kuninaka Y, et al. A case of complex suicide due to acute nicotine intoxication caused by cigarette ingestion. Int J Legal Med. 2019. https://doi.org/10.1007/s00414-019-02228-5 .
Chang JT, Rostron BL. Electronic nicotine delivery system (ENDS) liquid nicotine exposure in young children presenting to US emergency departments, 2018. Inj Epidemiol. 2019;6:43.
Solarino B, Rosenbaum F, Rießelmann B, Buschmann CT, Tsokos M. Death due to ingestion of nicotine-containing solution: case report and review of the literature. Forensic Sci Int. 2010;195(1–3):e19–22.
Wang B, Liu S, Persoskie A. Poisoning exposure cases involving e-cigarettes and e-liquid in the United States, 2010–2018. Clin Toxicol. 2019. https://doi.org/10.1080/15563650.2019.1661426 .
Ang E, Tuthill D, Thompson J. E-cigarette liquid ingestion: a fast growing accidental issue in children. Arch Dis Child. BMJ Publishing Group. 2018;103:1091.
Kozlowski LT, Mehta NY, Sweeney CT, Schwartz SS, Vogler GP, Jarvis MJ, et al. Filter ventilation and nicotine content of tobacco in cigarettes from Canada, the United Kingdom, and the United States. Tob Control. 1998;7(4):369–75.
doi: 10.1136/tc.7.4.369
Maxwell JC. The Maxwell report: year end & fourth quarter 2017 cigarette industry. Richmond: John C. Maxwell, Jr; 2018.
Mayer B. How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century. Arch Toxicol. 2014;88:5–7.
Dart RC, McGuigan MA. Nicotine. In: Dart RC, editor. Medical Toxicology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2003. p. 601–4.
Mensch AR, Holden M. Nicotine overdose after a single piece of nicotine gum. Chest. 1984;86:801–2.
Soghoian S. Nicotine. Goldfranks Toxicologic Emergencies. Tenth ed. New York: McGraw-Hill; 2015. p. 1139.
Maina G, Castagnoli C, Passini V, et al. Transdermal nicotine absorption handling e-cigarette refill liquids. Regul Toxicol Pharmacol. 2016;74:31–3.
Richardson JF, Harker JH, Backhurst JR. In: Richardson JF, Harker JH, Backhurst JR, editors. “Chapter 10 – leaching”, chemical engineering (fifth), chemical engineering series. Oxford: Butterworth-Heinemann; 2002. p. 502–541.
Prosser AP. Review of uncertainty in the collection and interpretation of leaching data. Hydrometallurgy. 1996;41(2):119–53.
doi: 10.1016/0304-386X(95)00071-N