Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin-treated type 2 diabetes: The Fukuoka Diabetes Registry.
Adiponectin
/ blood
Aged
Biomarkers
/ blood
Blood Glucose
/ analysis
Diabetes Mellitus, Type 1
/ drug therapy
Diabetes Mellitus, Type 2
/ drug therapy
Female
Follow-Up Studies
Humans
Hypoglycemia
/ blood
Hypoglycemic Agents
/ adverse effects
Incidence
Japan
/ epidemiology
Male
Middle Aged
Prognosis
Prospective Studies
Registries
/ statistics & numerical data
Risk Factors
Adiponectin
Hypoglycemia
Insulin
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
18
12
2019
revised:
25
02
2020
accepted:
15
03
2020
pubmed:
18
3
2020
medline:
15
9
2021
entrez:
18
3
2020
Statut:
ppublish
Résumé
The incidence of severe hypoglycemia and its risk factors including an insulin-sensitizing adipokine, adiponectin, were prospectively investigated in Japanese patients with type 1 or insulin-treated type 2 diabetes. A total of 207 participants with type 1 diabetes (mean age 55 years) and 1,396 with insulin-treated type 2 diabetes (mean age 65 years) from the local diabetes registry were followed for 5 years (follow-up rate 99%). Severe hypoglycemia was defined as events requiring the assistance of others for recovery from hypoglycemia. The incidence of severe hypoglycemia was 9.2 per 100 person-years in those with type 1 diabetes, and 2.3 per 100 person-years in those with insulin-treated type 2 diabetes, respectively. For type 1 diabetes, the risk was significant in those with a history of severe hypoglycemia within the previous year, slow eating and higher serum adiponectin (the highest vs the lowest in quartile hazard ratio 2.36, 95% confidence interval 1.22-4.69). For insulin-treated type 2 diabetes, the risk included age ≥65 years, history of severe hypoglycemia within the previous year, alcohol consumption ≥60 g/day, larger insulin dose and higher serum adiponectin (the highest vs the lowest in quartile, hazard ratio 2.95, 95% confidence interval 1.22-4.69). For all participants, the incidence of severe hypoglycemia increased along with serum adiponectin (age- and sex-adjusted hazard ratio 1.65 per 1 standard deviation increase of log serum adiponectin, 95% confidence interval 1.45-1.87). The incidence of severe hypoglycemia was prospectively determined, and the association between severe hypoglycemia and higher serum adiponectin was observed in Japanese patients with type 1 and insulin-treated type 2 diabetes.
Identifiants
pubmed: 32180356
doi: 10.1111/jdi.13253
pmc: PMC7477501
doi:
Substances chimiques
ADIPOQ protein, human
0
Adiponectin
0
Biomarkers
0
Blood Glucose
0
Hypoglycemic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1258-1264Subventions
Organisme : The Japan Society for the Promotion of Science
ID : 23249037, 23659353, 16K00861
Organisme : Japan Diabetes Society
ID : Junior Scientist Development Grant
Informations de copyright
© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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