Wikidata as a knowledge graph for the life sciences.

computational biology data mining drug repurposing knowledge graphs none science forum systems biology wikidata

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
17 03 2020
Historique:
received: 09 10 2019
accepted: 28 02 2020
entrez: 18 3 2020
pubmed: 18 3 2020
medline: 15 4 2021
Statut: epublish

Résumé

Wikidata is a community-maintained knowledge base that has been assembled from repositories in the fields of genomics, proteomics, genetic variants, pathways, chemical compounds, and diseases, and that adheres to the FAIR principles of findability, accessibility, interoperability and reusability. Here we describe the breadth and depth of the biomedical knowledge contained within Wikidata, and discuss the open-source tools we have built to add information to Wikidata and to synchronize it with source databases. We also demonstrate several use cases for Wikidata, including the crowdsourced curation of biomedical ontologies, phenotype-based diagnosis of disease, and drug repurposing.

Identifiants

pubmed: 32180547
doi: 10.7554/eLife.52614
pii: 52614
pmc: PMC7077981
doi:
pii:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI126785
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG003751
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103504
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM114833
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA209936
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM089820
Pays : United States
Organisme : NHGRI NIH HHS
ID : P41 HG003751
Pays : United States
Organisme : NHGRI NIH HHS
ID : R00 HG007940
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM100039
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002550
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA237719
Pays : United States

Informations de copyright

© 2020, Waagmeester et al.

Déclaration de conflit d'intérêts

AW, GS, SB, BG, MG, OG, KH, HH, TH, KH, SK, MM, MM, DM, EM, AP, TP, AR, NQ, LS, TS, DS, RS, KT, GT, RT, SU, EW, CW, AS No competing interests declared

Références

J Biomed Inform. 2009 Jun;42(3):530-9
pubmed: 19475726
Am J Hum Genet. 2009 Oct;85(4):457-64
pubmed: 19800049
Database (Oxford). 2016 Mar 17;2016:
pubmed: 26989148
Eur J Med Genet. 2015 Jan;58(1):39-43
pubmed: 25220016
Nucleic Acids Res. 2014 Jan;42(Database issue):D1098-106
pubmed: 24234439
Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515
pubmed: 30395287
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W623-33
pubmed: 19498078
Nat Biotechnol. 2019 Apr;37(4):358-367
pubmed: 30940948
Database (Oxford). 2009;2009:bap017
pubmed: 20157490
F1000Res. 2017 Nov 27;6:
pubmed: 29333230
Genet Med. 2014 Oct;16(10):751-8
pubmed: 24651605
Nucleic Acids Res. 2018 Jan 4;46(D1):D8-D13
pubmed: 29140470
Nucleic Acids Res. 2019 Jan 8;47(D1):D427-D432
pubmed: 30357350
Nucleic Acids Res. 2019 Jan 8;47(D1):D520-D528
pubmed: 30357364
Sci Data. 2019 Sep 20;6(1):174
pubmed: 31541130
Am J Hum Genet. 2007 Apr;80(4):588-604
pubmed: 17357067
Curr Protoc Bioinformatics. 2017 Jun 27;58:1.2.1-1.2.12
pubmed: 28654725
BMC Bioinformatics. 2018 Feb 01;19(1):30
pubmed: 29390967
Nucleic Acids Res. 2019 Jan 8;47(D1):D955-D962
pubmed: 30407550
J Am Med Inform Assoc. 2011 Jul-Aug;18(4):441-8
pubmed: 21515544
Database (Oxford). 2012 May 02;2012:bas024
pubmed: 22554788
Database (Oxford). 2016 Mar 17;2016:
pubmed: 26989150
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D267-70
pubmed: 14681409
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106
pubmed: 29149325
J Cheminform. 2017 Nov 28;9(1):61
pubmed: 29185060
Sci Data. 2016 Mar 15;3:160018
pubmed: 26978244
Nat Biotechnol. 2016 Nov 8;34(11):1099-1101
pubmed: 27824832
Database (Oxford). 2014 Jul 22;2014:
pubmed: 25052702
Elife. 2017 Sep 22;6:
pubmed: 28936969
Sci Data. 2018 May 08;5:180029
pubmed: 29737976
Nucleic Acids Res. 2019 Jan 8;47(D1):D351-D360
pubmed: 30398656
Nucleic Acids Res. 2017 Jan 4;45(D1):D865-D876
pubmed: 27899602
Nucleic Acids Res. 2005 Jan 1;33(Database issue):D238-41
pubmed: 15608186
Nat Genet. 2017 Jan 31;49(2):170-174
pubmed: 28138153
Database (Oxford). 2019 Jan 1;2019:
pubmed: 30985891
Nat Biotechnol. 2016 Aug 9;34(8):828-837
pubmed: 27504778
Bioinformatics. 2012 Oct 1;28(19):2502-8
pubmed: 22843981
J Biomed Inform. 2019 Nov;99:103292
pubmed: 31557529
Nucleic Acids Res. 2018 Jan 4;46(D1):D754-D761
pubmed: 29155950
BMC Bioinformatics. 2010 Jan 04;11:5
pubmed: 20047655
Transl Sci Rare Dis. 2017 May 25;2(1-2):77-88
pubmed: 29152459
Nucleic Acids Res. 2017 Jan 4;45(D1):D932-D939
pubmed: 27789690
Nucleic Acids Res. 2015 Jul 1;43(W1):W589-98
pubmed: 25897122
Nucleic Acids Res. 2018 Jan 4;46(D1):D649-D655
pubmed: 29145629
Nucleic Acids Res. 2018 Jan 4;46(D1):D661-D667
pubmed: 29136241
J Mass Spectrom. 2010 Jul;45(7):703-14
pubmed: 20623627
Genet Med. 2017 Feb;19(2):160-168
pubmed: 27388694
Eur J Med Genet. 2018 Nov;61(11):706-714
pubmed: 29425702
Nucleic Acids Res. 2016 Jan 4;44(D1):D1054-68
pubmed: 26464438
Database (Oxford). 2017 Jan 1;2017(1):
pubmed: 28365742
Nucleic Acids Res. 2017 Jan 4;45(D1):D712-D722
pubmed: 27899636
Nucleic Acids Res. 2007 Jan;35(Database issue):D527-32
pubmed: 17098933

Auteurs

Gregory Stupp (G)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Sebastian Burgstaller-Muehlbacher (S)

Center for Integrative Bioinformatics Vienna, Max Perutz Laboratories, University of Vienna and Medical University of Vienna, Vienna, Austria.

Benjamin M Good (BM)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Malachi Griffith (M)

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, United States.

Obi L Griffith (OL)

McDonnell Genome Institute, Washington University School of Medicine, St. Louis, United States.

Kristina Hanspers (K)

Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, United States.

Henning Hermjakob (H)

European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom.

Toby S Hudson (TS)

School of Chemistry, The University of Sydney, Sydney, Australia.

Kevin Hybiske (K)

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, United States.

Sarah M Keating (SM)

European Bioinformatics Institute (EMBL-EBI), Hinxton, United Kingdom.

Magnus Manske (M)

Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

Michael Mayers (M)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Daniel Mietchen (D)

School of Data Science, University of Virginia, Charlottesville, United States.

Elvira Mitraka (E)

University of Maryland School of Medicine, Baltimore, United States.

Alexander R Pico (AR)

Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, United States.

Timothy Putman (T)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Anders Riutta (A)

Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, United States.

Nuria Queralt-Rosinach (N)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Lynn M Schriml (LM)

University of Maryland School of Medicine, Baltimore, United States.

Thomas Shafee (T)

Department of Animal Plant and Soil Sciences, La Trobe University, Melbourne, Australia.

Denise Slenter (D)

Department of Bioinformatics-BiGCaT, NUTRIM, Maastricht University, Maastricht, Netherlands.

Ralf Stephan (R)

Retired researcher, Berlin, Germany.

Katherine Thornton (K)

Yale University Library, Yale University, New Haven, United States.

Ginger Tsueng (G)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Roger Tu (R)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Sabah Ul-Hasan (S)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Egon Willighagen (E)

Department of Bioinformatics-BiGCaT, NUTRIM, Maastricht University, Maastricht, Netherlands.

Chunlei Wu (C)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

Andrew I Su (AI)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

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