Acute and Chronic Nicotine Exposures Differentially Affect Central Serotonin 2A Receptor Function: Focus on the Lateral Habenula.

5-HT2CR addiction dentate gyrus depression dorsal raphe nucleus medial prefrontal cortex nucleus accumbens striatum substantia nigra pars compacta ventral tegmental area

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
09 Mar 2020
Historique:
received: 03 02 2020
accepted: 06 03 2020
entrez: 19 3 2020
pubmed: 19 3 2020
medline: 15 12 2020
Statut: epublish

Résumé

Nicotine addiction is a serious public health problem causing millions of deaths worldwide. Serotonin (5-hydroxytryptamine; 5-HT) is involved in central nervous system (CNS) nicotine effects, and it has been suggested as a promising pharmacological target for smoking cessation. In this regard, what is particularly interesting are the 5-HT

Identifiants

pubmed: 32182934
pii: ijms21051873
doi: 10.3390/ijms21051873
pmc: PMC7084359
pii:
doi:

Substances chimiques

Receptor, Serotonin, 5-HT2A 0
Serotonin 333DO1RDJY
Nicotine 6M3C89ZY6R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Cristiano Bombardi (C)

Dipartimento di Scienze Mediche Veterinarie, Università di Bologna, Bologna, Via Tolara di Sopra, 50, 40064 Ozzano dell'Emilia (BO), Italy.

Francis Delicata (F)

Department of Physiology and Biochemistry, Laboratory of Neurophysiology, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta.

Claudio Tagliavia (C)

Dipartimento di Scienze Mediche Veterinarie, Università di Bologna, Bologna, Via Tolara di Sopra, 50, 40064 Ozzano dell'Emilia (BO), Italy.

Massimo Pierucci (M)

Department of Physiology and Biochemistry, Laboratory of Neurophysiology, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta.

Gabriele Deidda (G)

Department of Physiology and Biochemistry, Laboratory of Neurophysiology, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta.

Maurizio Casarrubea (M)

Department of Biomedicine, Neuroscience and Advances Diagnosis (BIND), Human Physiology Section "Giuseppe Pagano", Laboratory of Behavioral Physiology, University of Palermo, Viale delle Scienze n. 13, 90128 Palermo, Italy.

Philippe De Deurwaerdère (P)

Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5287), 146 rue Léo Saignat, B.P.281, F-33000 Bordeaux Cedex, France.

Giuseppe Di Giovanni (G)

Department of Physiology and Biochemistry, Laboratory of Neurophysiology, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta.
School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

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Classifications MeSH