Induction of Apoptosis by Gluconasturtiin-Isothiocyanate (GNST-ITC) in Human Hepatocarcinoma HepG2 Cells and Human Breast Adenocarcinoma MCF-7 Cells.
apoptosis
cancer chemoprevention
gluconasturtiin-isothiocyanate
glucosinolate
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
09 Mar 2020
09 Mar 2020
Historique:
received:
12
11
2019
revised:
02
12
2019
accepted:
05
12
2019
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
18
12
2020
Statut:
epublish
Résumé
Gluconasturtiin, a glucosinolate present in watercress, is hydrolysed by myrosinase to form gluconasturtiin-isothiocyanate (GNST-ITC), which has potential chemopreventive effects; however, the underlying mechanisms of action have not been explored, mainly in human cell lines. The purpose of the study is to evaluate the cytotoxicity of GNST-ITC and to further assess its potential to induce apoptosis. GNST-ITC inhibited cell proliferation in both human hepatocarcinoma (HepG2) and human breast adenocarcinoma (MCF-7) cells with IC
Identifiants
pubmed: 32182965
pii: molecules25051240
doi: 10.3390/molecules25051240
pmc: PMC7179403
pii:
doi:
Substances chimiques
Glucosinolates
0
Isothiocyanates
0
gluconasturtiin
163ENC977A
isothiocyanic acid
3129-90-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Higher Education, Malaysia and Universiti Putra Malaysia
ID : GP-IPM (Vot No. 9400600).
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