Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells.
bioenergetics
gasotransmitters
hydrogen sulfide
migration
mitochondria
nitric oxide
proliferation
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
13 03 2020
13 03 2020
Historique:
received:
25
02
2020
revised:
10
03
2020
accepted:
12
03
2020
entrez:
19
3
2020
pubmed:
19
3
2020
medline:
20
3
2021
Statut:
epublish
Résumé
3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant sources of biologically active sulfur species in various mammalian cells. The current study was designed to investigate the functional role of 3-MST's catalytic activity in the murine colon cancer cell line CT26. The novel pharmacological 3-MST inhibitor HMPSNE was used to assess cancer cell proliferation, migration and bioenergetics in vitro. Methods included measurements of cell viability (MTT and LDH assays), cell proliferation and in vitro wound healing (IncuCyte) and cellular bioenergetics (Seahorse extracellular flux analysis). 3-MST expression was detected by Western blotting; H
Identifiants
pubmed: 32183148
pii: biom10030447
doi: 10.3390/biom10030447
pmc: PMC7175125
pii:
doi:
Substances chimiques
Neoplasm Proteins
0
Sulfurtransferases
EC 2.8.1.-
3-mercaptopyruvate sulphurtransferase
EC 2.8.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 31003A_179434
Pays : International
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