Atypical antipsychotic clozapine binds fibrinogen and affects fibrin formation.

Antipsychotic Agents / metabolism Clozapine / metabolism Dose-Response Relationship, Drug Fibrin / biosynthesis Fibrinogen / metabolism
Binding Clozapine Coagulation Fibrinogen Hemostasis Thrombosis

Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
01 Jul 2020
Historique:
received: 05 02 2020
revised: 12 03 2020
accepted: 13 03 2020
pubmed: 19 3 2020
medline: 16 2 2021
entrez: 19 3 2020
Statut: ppublish

Résumé

Clozapine is an atypical antipsychotic used for the treatment of schizophrenia. The prescribed target daily doses may reach 900 mg. Literature studies report a connection between clozapine usage and thrombosis development. Our in vitro study aimed to provide insight into molecular bases of this observation, investigating clozapine binding to fibrinogen, the main plasma protein involved in hemostasis. Fibrinogen/clozapine interaction was confirmed by protein fluorescence quenching, with an affinity constant of 1.7 × 10

Identifiants

DOI: 10.1016/j.ijbiomac.2020.03.119 PMID: 32184141
pubmed: 32184141
pii: S0141-8130(20)31147-8
doi: 10.1016/j.ijbiomac.2020.03.119
pii:
doi:

Substances chimiques

Antipsychotic Agents 0
Fibrin 9001-31-4
Fibrinogen 9001-32-5
Clozapine J60AR2IKIC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

142-149

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Auteurs

Nikola Gligorijević (N)

Institute for the Application of Nuclear Energy (INEP), Department of Metabolism, University of Belgrade, Banatska 31b, 11080 Zemun, Serbia.

Tamara Vasović (T)

University of Belgrade, Faculty of Chemistry, Department of Biochemistry & Centre of Excellence for Molecular Food Sciences, Studentski trg 12-16, 11000 Belgrade, Serbia.

Steva Lević (S)

Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Zemun, Serbia.

Čedo Miljević (Č)

Institute of Mental Health, School of Medicine, University of Belgrade, Palmotićeva 37, 11000 Belgrade, Serbia.

Olgica Nedić (O)

Institute for the Application of Nuclear Energy (INEP), Department of Metabolism, University of Belgrade, Banatska 31b, 11080 Zemun, Serbia.

Milan Nikolić (M)

University of Belgrade, Faculty of Chemistry, Department of Biochemistry & Centre of Excellence for Molecular Food Sciences, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: mnikolic@chem.bg.ac.rs.

Articles similaires

Post-translational modifications of fibrinogen: implications for clotting, fibrin structure and degradation.

Francesca Nencini, Alessandra Bettiol, Flavia Rita Argento et al.
1.00
Protein Processing, Post-Translational Humans Blood Coagulation Fibrin Fibrinogen

Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial.

Steven Perrin, Shafeeq Ladha, Nicholas Maragakis et al.
1.00
Humans Amyotrophic Lateral Sclerosis Male Middle Aged Female

Association of antipsychotic drugs on type 2 diabetes mellitus risk in patients with schizophrenia: a population-based cohort and in vitro glucose homeostasis-related gene expression study.

Yi-Jen Fang, Wan-Yi Lee, Cheng-Li Lin et al.
1.00
Humans Diabetes Mellitus, Type 2 Schizophrenia Antipsychotic Agents Male

A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds.

Ming Li, Chenxi Wang, Qiang Yu et al.
1.00
Animals Wound Healing Mice Wearable Electronic Devices Wound Infection

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Atypical antipsychotic clozapine binds...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzazépines › Clozapine › Atypical antipsychotic clozapine binds...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Atypical antipsychotic clozapine binds...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Fibrine › Atypical antipsychotic clozapine binds...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Fibrinogène › Atypical antipsychotic clozapine binds...