Lung developmental arrest caused by PDGF-A deletion: consequences for the adult mouse lung.
PDGF-A
lung
mouse model
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
pubmed:
19
3
2020
medline:
17
7
2020
entrez:
19
3
2020
Statut:
ppublish
Résumé
PDGF-A is a key contributor to lung development in mice. Its expression is needed for secondary septation of the alveoli and deletion of the gene leads to abnormally enlarged alveolar air spaces in mice. In humans, the same phenotype is the hallmark of bronchopulmonary dysplasia (BPD), a disease that affects premature babies and may have long lasting consequences in adulthood. So far, the knowledge regarding adult effects of developmental arrest in the lung is limited. This is attributable to few follow-up studies of BPD survivors and lack of good experimental models that could help predict the outcomes of this early age disease for the adult individual. In this study, we used the constitutive lung-specific
Identifiants
pubmed: 32186397
doi: 10.1152/ajplung.00295.2019
pmc: PMC7191480
doi:
Substances chimiques
Platelet-Derived Growth Factor
0
platelet-derived growth factor A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
L831-L843Références
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