New thiazolyl-pyrazoline derivatives bearing nitrogen mustard as potential antimicrobial and antiprotozoal agents.
Anti-Bacterial Agents
/ chemical synthesis
Antiprotozoal Agents
/ chemical synthesis
Dose-Response Relationship, Drug
Leishmania
/ drug effects
Mechlorethamine
/ chemistry
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Microbial Sensitivity Tests
Molecular Structure
Parasitic Sensitivity Tests
Plasmodium falciparum
/ drug effects
Pyrazoles
/ chemistry
Structure-Activity Relationship
Thiazoles
/ chemistry
Trypanosoma cruzi
/ drug effects
Vancomycin-Resistant Staphylococcus aureus
/ drug effects
antibacterial activity
antifungal activity
antiprotozoal activity
chalcone
pyrazoline
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
received:
25
11
2019
revised:
24
02
2020
accepted:
25
02
2020
pubmed:
19
3
2020
medline:
31
12
2020
entrez:
19
3
2020
Statut:
ppublish
Résumé
A new series of N-substituted pyrazoline derivatives 6a-g, 7a-g, 8a-g, and 9a-g was synthetized by reaction of hydrazine derivatives and chalcone-thiazole hybrids bearing nitrogen mustard 5a-g. The chalcones 5a-g were obtained by Claisen-Schmidt condensation of thiazole-2-nitrogen mustard 3 and selected acetophenones 4a-g. These new compounds 6/7/8/9a-g were screened for their antifungal activity against Cryptococcus neoformans, with IC
Identifiants
pubmed: 32187709
doi: 10.1002/ardp.201900351
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antiprotozoal Agents
0
Pyrazoles
0
Thiazoles
0
Mechlorethamine
50D9XSG0VR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900351Subventions
Organisme : Science, Technology, and Innovation Fund-General Royalties System (FCTeI-SGR)
ID : BPIN 2013000100007
Organisme : Consejería de Innovación, Ciencia y Empresa (Junta de Andalucía, Spain)
Organisme : Universidad de Jaén
Organisme : Universidad del Valle
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT2016-1833
Organisme : Departamento Administrativo de Ciencia, Tecnología e Innovación
ID : 110680864255
Organisme : National University of Rosario Argentina
Informations de copyright
© 2020 Deutsche Pharmazeutische Gesellschaft.
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