Focal and generalized seizure activity after local hippocampal or cortical ablation of Na


Journal

Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R

Informations de publication

Date de publication:
04 2020
Historique:
received: 05 12 2019
revised: 26 02 2020
accepted: 26 02 2020
pubmed: 20 3 2020
medline: 21 10 2020
entrez: 20 3 2020
Statut: ppublish

Résumé

Early onset seizures are a hallmark of Dravet syndrome. Previous studies in rodent models have shown that the epileptic phenotype is caused by loss-of-function of voltage-gated Na

Identifiants

pubmed: 32190912
doi: 10.1111/epi.16482
pmc: PMC7216883
doi:

Substances chimiques

NAV1.1 Voltage-Gated Sodium Channel 0
Scn1a protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e30-e36

Subventions

Organisme : Dutch National Epilepsy Foundation
ID : NEF 2017-10
Pays : International

Informations de copyright

© 2020 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.

Références

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pubmed: 32190912
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pubmed: 23663038

Auteurs

Nico A Jansen (NA)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Anisa Dehghani (A)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Cor Breukel (C)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Else A Tolner (EA)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Arn M J M van den Maagdenberg (AMJM)

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

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Classifications MeSH