PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice.
NAFLD
NASH
PPAR
insulin resistance
liver fibrosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Mar 2020
17 Mar 2020
Historique:
received:
21
02
2020
revised:
09
03
2020
accepted:
09
03
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and liver cancer. PPARβ/δ promotes fatty acid β-oxidation largely in extrahepatic organs, and PPARγ stores triacylglycerol in adipocytes. Investigations using liver-specific PPAR-disrupted mice have revealed major but distinct contributions of the three PPARs in the liver. This review summarizes the findings of liver-specific PPAR-null mice and discusses the role of PPARs in the liver.
Identifiants
pubmed: 32192216
pii: ijms21062061
doi: 10.3390/ijms21062061
pmc: PMC7139552
pii:
doi:
Substances chimiques
Peroxisome Proliferator-Activated Receptors
0
Protein Isoforms
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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