PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
17 Mar 2020
Historique:
received: 21 02 2020
revised: 09 03 2020
accepted: 09 03 2020
entrez: 21 3 2020
pubmed: 21 3 2020
medline: 15 12 2020
Statut: epublish

Résumé

Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and liver cancer. PPARβ/δ promotes fatty acid β-oxidation largely in extrahepatic organs, and PPARγ stores triacylglycerol in adipocytes. Investigations using liver-specific PPAR-disrupted mice have revealed major but distinct contributions of the three PPARs in the liver. This review summarizes the findings of liver-specific PPAR-null mice and discusses the role of PPARs in the liver.

Identifiants

pubmed: 32192216
pii: ijms21062061
doi: 10.3390/ijms21062061
pmc: PMC7139552
pii:
doi:

Substances chimiques

Peroxisome Proliferator-Activated Receptors 0
Protein Isoforms 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Yaping Wang (Y)

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.

Takero Nakajima (T)

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.

Frank J Gonzalez (FJ)

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Naoki Tanaka (N)

Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan.
Research Center for Social Systems, Shinshu University, Matsumoto, Nagano 390-8621, Japan.

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