Ca
Anti-Bacterial Agents
/ pharmacology
Biosynthetic Pathways
/ drug effects
Cell Wall
/ drug effects
Daptomycin
/ pharmacology
Humans
Membrane Lipids
/ metabolism
Membranes, Artificial
Methicillin-Resistant Staphylococcus aureus
/ drug effects
Microbial Sensitivity Tests
Phosphatidylglycerols
/ metabolism
Polyisoprenyl Phosphates
/ metabolism
Staphylococcal Infections
/ drug therapy
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
19 03 2020
19 03 2020
Historique:
received:
15
07
2019
accepted:
25
02
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
14
7
2020
Statut:
epublish
Résumé
The lipopeptide daptomycin is used as an antibiotic to treat severe infections with gram-positive pathogens, such as methicillin resistant Staphylococcus aureus (MRSA) and drug-resistant enterococci. Its precise mechanism of action is incompletely understood, and a specific molecular target has not been identified. Here we show that Ca
Identifiants
pubmed: 32193379
doi: 10.1038/s41467-020-15257-1
pii: 10.1038/s41467-020-15257-1
pmc: PMC7081307
doi:
Substances chimiques
Anti-Bacterial Agents
0
Membrane Lipids
0
Membranes, Artificial
0
Phosphatidylglycerols
0
Polyisoprenyl Phosphates
0
undecaprenyl phosphate
25126-51-6
undecaprenyl pyrophosphate
31867-59-1
Daptomycin
NWQ5N31VKK
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1455Subventions
Organisme : NIAID NIH HHS
ID : R01 AI132627
Pays : United States
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