Coronaridine congeners potentiate GABA
Coronaridine congeners
GABA(A) receptors
Glycine receptors
Positive allosteric modulators
Sedative activity
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
13 07 2020
13 07 2020
Historique:
received:
30
11
2019
revised:
13
03
2020
accepted:
15
03
2020
pubmed:
21
3
2020
medline:
5
6
2021
entrez:
21
3
2020
Statut:
ppublish
Résumé
To determine whether (+)-catharanthine induces sedative- or anxiolytic/anxiogenic-like activity in male mice, proper animal paradigms were used. The results showed that (+)-catharanthine induces sedative-like activity in the 63-72 mg/Kg dose range in a flumazenil-insensitive manner, but neither this effect nor anxiolytic/anxiogenic-like activity was observed at lower doses. To determine the underlying molecular mechanism of the sedative-like activity, electrophysiological and radioligand binding experiments were performed with (+)-catharanthine and (±)-18-methoxycoronaridine [(±)-18-MC] on GABA
Identifiants
pubmed: 32194202
pii: S0278-5846(19)31019-X
doi: 10.1016/j.pnpbp.2020.109930
pii:
doi:
Substances chimiques
GABA-A Receptor Agonists
0
Hypnotics and Sedatives
0
Receptors, GABA-A
0
Benzodiazepines
12794-10-4
Ibogaine
3S814I130U
coronardine
467-77-6
noribogaine
87T5QTN9SK
18-methoxycoronaridine
KX8NQX91Z8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109930Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no conflict of interest.