pH-Dependent Grafting of Cancer Cells with Antigenic Epitopes Promotes Selective Antibody-Mediated Cytotoxicity.
2,4-Dinitrophenol
/ chemistry
Amino Acid Sequence
Animals
Antibodies, Monoclonal
/ immunology
Cell Line, Tumor
Epitopes
/ chemistry
Fluorescein-5-isothiocyanate
/ chemistry
Humans
Hydrogen-Ion Concentration
Immunologic Factors
/ chemistry
Immunotherapy
/ methods
Killer Cells, Natural
/ drug effects
Membrane Proteins
/ chemistry
Mice
Neoplasms
/ metabolism
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
09 04 2020
09 04 2020
Historique:
pubmed:
21
3
2020
medline:
8
10
2020
entrez:
21
3
2020
Statut:
ppublish
Résumé
A growing class of immunotherapeutics work by redirecting components of the immune system to recognize markers on the surface of cancer cells. However, such modalities will remain confined to a relatively small subgroup of patients because of the lack of universal targetable tumor biomarkers among all patients. Here, we designed a unique class of agents that exploit the inherent acidity of solid tumors to selectively graft cancer cells with immuno-engager epitopes. Our targeting approach is based on pHLIP, a unique peptide that selectively targets tumors
Identifiants
pubmed: 32196345
doi: 10.1021/acs.jmedchem.0c00016
pmc: PMC7263447
mid: NIHMS1592995
doi:
Substances chimiques
Antibodies, Monoclonal
0
Epitopes
0
Immunologic Factors
0
Membrane Proteins
0
pHLIP protein
0
Fluorescein-5-isothiocyanate
I223NX31W9
2,4-Dinitrophenol
Q13SKS21MN
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3713-3722Subventions
Organisme : NCI NIH HHS
ID : R21 CA181868
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124893
Pays : United States
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