Neurodevelopmental outcomes following intravitreal bevacizumab injection in Japanese preterm infants with type 1 retinopathy of prematurity.
Angiogenesis Inhibitors
/ adverse effects
Bevacizumab
/ adverse effects
Developmental Disabilities
/ etiology
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Intravitreal Injections
Japan
Language Development Disorders
/ etiology
Laser Coagulation
Multivariate Analysis
Retinopathy of Prematurity
/ drug therapy
Retrospective Studies
Severity of Illness Index
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
10
2019
accepted:
05
03
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
1
7
2020
Statut:
epublish
Résumé
The purpose of this study was to evaluate neurodevelopmental outcomes in 18-month old (corrected age) preterm infants who received an intravitreal bevacizumab (IVB) injection for the treatment of type 1 retinopathy of prematurity (ROP). In this ten-year retrospective study, we reviewed the medical records of patients who underwent ROP screening at Kyushu University Hospital. Among the patients who received IVB or laser photocoagulation (LPC) for the treatment of type 1 ROP, we included infants whose neurodevelopmental examination (the Kyoto Scale of Psychological Development [KSPD]) results at 18 months corrected age were available. Then, the effect of IVB on the developmental quotient (DQ) in each KSPD domain (Postural-Movement, Cognitive-Adaptive, or Language-Social domain) or the overall DQ was investigated by performing linear regression analysis. Out of the 513 patients reviewed, 53 were included in the study. IVB and LPC were performed for 14 and 39 patients, respectively. Administration of IVB was significantly associated with neurodevelopmental delay in the Language-Social domain (p = 0.01). The observed association remained even after adjusting for gestational age and birth weight (p = 0.03). Administration of IVB may introduce a risk of developmental impairment of interpersonal relationships, socializations, and/or verbal abilities of preterm children. We recommended that preterm infants who received IVB undergo a neurodevelopmental reassessment during their school years or in adulthood.
Identifiants
pubmed: 32196539
doi: 10.1371/journal.pone.0230678
pii: PONE-D-19-27961
pmc: PMC7083318
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Bevacizumab
2S9ZZM9Q9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0230678Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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