Sodium-glucose cotransporters: Functional properties and pharmaceutical potential.
Antidiabetic drugs
Sodium-glucose cotransporter 1
Sodium-glucose cotransporter 2
Journal
Journal of diabetes investigation
ISSN: 2040-1124
Titre abrégé: J Diabetes Investig
Pays: Japan
ID NLM: 101520702
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
03
01
2020
revised:
06
03
2020
accepted:
13
03
2020
pubmed:
21
3
2020
medline:
7
7
2021
entrez:
21
3
2020
Statut:
ppublish
Résumé
Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium-glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.
Identifiants
pubmed: 32196987
doi: 10.1111/jdi.13255
pmc: PMC7378437
doi:
Substances chimiques
Hypoglycemic Agents
0
Sodium-Glucose Transport Proteins
0
Sodium-Glucose Transporter 1
0
Sodium-Glucose Transporter 2
0
Sodium-Glucose Transporter 2 Inhibitors
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
770-782Informations de copyright
© 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
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