Targeting of G-protein coupled receptors in sepsis.
Aptamers
G-protein coupled receptors
Intrabodies
Pepducins
Sepsis
Septic shock
Journal
Pharmacology & therapeutics
ISSN: 1879-016X
Titre abrégé: Pharmacol Ther
Pays: England
ID NLM: 7905840
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
24
12
2019
revised:
11
03
2020
accepted:
11
03
2020
pubmed:
22
3
2020
medline:
28
5
2021
entrez:
22
3
2020
Statut:
ppublish
Résumé
The Third International Consensus Definitions (Sepsis-3) define sepsis as life-threatening multi-organ dysfunction caused by a dysregulated host response to infection. Sepsis can progress to septic shock-an even more lethal condition associated with profound circulatory, cellular and metabolic abnormalities. Septic shock remains a leading cause of death in intensive care units and carries a mortality of almost 25%. Despite significant advances in our understanding of the pathobiology of sepsis, therapeutic interventions have not translated into tangible differences in the overall outcome for patients. Clinical trials of antagonists of various pro-inflammatory mediators in sepsis have been largely unsuccessful in the past. Given the diverse physiologic roles played by G-protein coupled receptors (GPCR), modulation of GPCR signaling for the treatment of sepsis has also been explored. Traditional pharmacologic approaches have mainly focused on ligands targeting the extracellular domains of GPCR. However, novel techniques aimed at modulating GPCR intracellularly through aptamers, pepducins and intrabodies have opened a fresh avenue of therapeutic possibilities. In this review, we summarize the diverse roles played by various subfamilies of GPCR in the pathogenesis of sepsis and identify potential targets for pharmacotherapy through these novel approaches.
Identifiants
pubmed: 32197794
pii: S0163-7258(20)30057-7
doi: 10.1016/j.pharmthera.2020.107529
pmc: PMC7388546
mid: NIHMS1577577
pii:
doi:
Substances chimiques
Ligands
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107529Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK113790
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM066189
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest GH owns stock in Purine Pharmaceuticals, Inc. and has patents related to purinergic signaling in sepsis. All other authors have no conflict of interests to disclose.
Références
Am J Respir Crit Care Med. 2001 Oct 1;164(7):1213-20
pubmed: 11673212
Br J Clin Pharmacol. 2016 Jul;82(1):139-48
pubmed: 26852904
Pharmacol Res Perspect. 2015 Nov 16;3(6):e00189
pubmed: 27022463
Ophthalmic Physiol Opt. 2002 Sep;22(5):359-65
pubmed: 12358303
Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):189-97
pubmed: 26681756
Free Radic Biol Med. 2011 May 15;50(10):1368-81
pubmed: 21362471
Crit Care Med. 2001 Apr;29(4):703-8
pubmed: 11373452
J Immunol. 2006 Sep 1;177(5):2765-9
pubmed: 16920910
J Exp Med. 2013 Feb 11;210(2):257-68
pubmed: 23382542
Nature. 2014 Jun 5;510(7503):92-101
pubmed: 24899309
Br J Pharmacol. 1998 Nov;125(6):1297-303
pubmed: 9863660
Cell. 1990 Nov 2;63(3):601-8
pubmed: 2225067
FASEB J. 2006 Jan;20(1):187-9
pubmed: 16280366
Annu Rev Pharmacol Toxicol. 2004;44:43-66
pubmed: 14744238
Naunyn Schmiedebergs Arch Pharmacol. 2004 Nov;370(5):347-52
pubmed: 15526105
Int J Mol Med. 2001 Dec;8(6):617-21
pubmed: 11712075
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8491-6
pubmed: 21536878
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14983-8
pubmed: 22927428
Nat Med. 2002 Oct;8(10):1161-5
pubmed: 12357249
Br J Pharmacol. 1998 Sep;125(2):379-87
pubmed: 9786512
Eur J Pharmacol. 2018 Jan 5;818:457-469
pubmed: 29133126
Mol Pharmacol. 2014 Nov;86(5):479-84
pubmed: 24890609
Am J Respir Crit Care Med. 2013 Jun 15;187(12):1287-93
pubmed: 23590272
Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):865-9
pubmed: 22423038
J Clin Invest. 2012 Nov;122(11):3931-42
pubmed: 23093781
Nat Rev Immunol. 2016 Jan;16(1):51-67
pubmed: 26688348
Arch Immunol Ther Exp (Warsz). 2015 Feb;63(1):41-52
pubmed: 25288367
Immunol Lett. 1995 Jul-Aug;47(1-2):133-7
pubmed: 8537090
J Am Chem Soc. 2011 Aug 24;133(33):13197-204
pubmed: 21766860
Adv Immunol. 2014;121:91-119
pubmed: 24388214
Br J Pharmacol. 2004 Jun;142(4):701-8
pubmed: 15159284
Annu Rev Biochem. 2013;82:637-62
pubmed: 23527695
Nature. 2016 Dec 15;540(7633):462-465
pubmed: 27926729
Am J Physiol Regul Integr Comp Physiol. 2006 Oct;291(4):R959-69
pubmed: 16728466
Biotechnol Adv. 2013 Dec;31(8):1676-94
pubmed: 23999358
Eur J Pharmacol. 2014 Oct 5;740:346-52
pubmed: 25041842
J Thromb Haemost. 2008 May;6(5):726-36
pubmed: 18284603
Neuropharmacology. 2017 Sep 15;124:13-24
pubmed: 28625718
Regul Pept. 2005 Nov;131(1-3):89-96
pubmed: 16043243
Blood. 2008 Sep 1;112(5):1822-31
pubmed: 18559975
Circ Res. 2016 Apr 29;118(9):1392-408
pubmed: 27126649
Int J Mol Sci. 2017 Nov 14;18(11):
pubmed: 29135922
Thromb Res. 2011 Jan;127 Suppl 2:S34-7
pubmed: 21193113
J Exp Med. 2007 Jun 11;204(6):1257-65
pubmed: 17502665
Drugs. 2016 Jul;76(11):1067-79
pubmed: 27318702
Crit Care Med. 2015 Sep;43(9):e332-40
pubmed: 25962080
Nat Rev Immunol. 2013 Nov;13(11):815-29
pubmed: 24319779
Trends Pharmacol Sci. 2009 Aug;30(8):411-20
pubmed: 19608284
Nat Immunol. 2013 Feb;14(2):162-71
pubmed: 23263555
J Endocrinol. 1995 Mar;144(3):457-62
pubmed: 7738470
Endocrinology. 2012 Jul;153(7):3426-34
pubmed: 22535766
Crit Care Med. 2001 Jul;29(7):1303-10
pubmed: 11445675
J Neuroimmunol. 2002 Jan;122(1-2):34-9
pubmed: 11777541
Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E211-20
pubmed: 20959533
J Immunol. 2007 Jul 15;179(2):901-9
pubmed: 17617581
J Thromb Haemost. 2005 Aug;3(8):1800-14
pubmed: 16102047
Br J Pharmacol. 2008 Jan;153(2):347-57
pubmed: 17994109
J Interferon Cytokine Res. 2017 Jul;37(7):325-329
pubmed: 28570146
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50
pubmed: 14722361
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
BMC Anesthesiol. 2015 May 01;15:68
pubmed: 25929655
J Immunol. 2010 Nov 1;185(9):5628-36
pubmed: 20870944
Drug Discov Today. 2014 Aug;19(8):1051-68
pubmed: 24607729
Intensive Care Med Exp. 2018 Aug 14;6(1):26
pubmed: 30112605
Crit Care Med. 2001 Jul;29(7 Suppl):S21-7
pubmed: 11445730
J Leukoc Biol. 2008 Mar;83(3):467-70
pubmed: 17875813
Neurotherapeutics. 2015 Oct;12(4):692-8
pubmed: 26271952
Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1228-37
pubmed: 26996596
Br J Pharmacol. 2006 Feb;147 Suppl 2:S88-119
pubmed: 16465187
Exp Biol Med (Maywood). 2002 Sep;227(8):645-51
pubmed: 12192108
J Immunol. 2009 Jul 1;183(1):499-505
pubmed: 19525393
Drug Discov Today. 2012 Apr;17(7-8):359-66
pubmed: 22033198
Front Endocrinol (Lausanne). 2014 May 13;5:67
pubmed: 24860547
J Immunol. 2013 Jan 1;190(1):138-46
pubmed: 23225885
J Immunol. 1996 Nov 15;157(10):4634-40
pubmed: 8906843
Shock. 2016 Sep;46(3):290-6
pubmed: 26925810
Diabetes. 2012 Feb;61(2):364-71
pubmed: 22190648
FASEB J. 2000 Oct;14(13):2065-74
pubmed: 11023991
J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):155-68
pubmed: 12503613
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9897-902
pubmed: 23716692
J Clin Invest. 1997 Sep 15;100(6):1513-9
pubmed: 9294119
Acta Anaesthesiol Scand. 2013 Jul;57(6):713-8
pubmed: 23683126
Eur J Pharmacol. 2006 Mar 8;533(1-3):15-27
pubmed: 16469310
Trends Pharmacol Sci. 2004 Mar;25(3):152-7
pubmed: 15019271
J Biol Chem. 2003 Jul 11;278(28):25481-9
pubmed: 12711604
Adv Pharmacol. 1995;34:155-70
pubmed: 8562431
Eur J Pharmacol. 2001 Nov 30;432(1):107-19
pubmed: 11734194
Trends Pharmacol Sci. 2005 Mar;26(3):131-7
pubmed: 15749158
J Leukoc Biol. 1991 Sep;50(3):279-86
pubmed: 1856598
N Engl J Med. 2017 Aug 3;377(5):414-417
pubmed: 28658587
J Leukoc Biol. 2006 Apr;79(4):767-78
pubmed: 16434695
J Anaesthesiol Clin Pharmacol. 2010 Oct;26(4):439-45
pubmed: 21547166
Curr Protein Pept Sci. 2018;19(9):924-934
pubmed: 28875851
Diabetes. 2014 Mar;63(3):850-66
pubmed: 24194503
J Immunol. 2010 Jul 1;185(1):542-50
pubmed: 20505145
Am J Respir Crit Care Med. 2007 Oct 15;176(8):805-13
pubmed: 17626913
Int Immunol. 2015 Mar;27(3):153-60
pubmed: 25344934
Neurosignals. 2009;17(1):42-54
pubmed: 19212139
FASEB J. 2012 Jan;26(1):376-86
pubmed: 21926236
Life Sci. 2006 Jul 24;79(9):905-12
pubmed: 16603198
JAMA. 2019 May 28;321(20):1978-1980
pubmed: 31104068
Mol Cell Endocrinol. 2012 Apr 4;351(2):152-66
pubmed: 22245784
Shock. 2019 Nov;52(5):e100-e106
pubmed: 30724784
Nature. 2016 Dec 15;540(7633):458-461
pubmed: 27926736
Br J Pharmacol. 2002 Apr;135(8):1889-96
pubmed: 11959791
Am J Pathol. 2009 Dec;175(6):2439-53
pubmed: 19850892
Cell Signal. 1993 Sep;5(5):505-18
pubmed: 8312128
J Neuroinflammation. 2013 Mar 19;10:40
pubmed: 23509933
J Immunol. 2001 Dec 15;167(12):6724-30
pubmed: 11739486
Am J Physiol Renal Physiol. 2012 Nov 15;303(10):F1443-53
pubmed: 22933299
Brain Res Bull. 1998;45(2):183-7
pubmed: 9443838
Immunol Rev. 2000 Oct;177:134-40
pubmed: 11138771
Eurasian J Med. 2016 Jun;48(2):135-41
pubmed: 27551178
N Engl J Med. 2010 Aug 12;363(7):689-91
pubmed: 20818861
Peptides. 2004 Oct;25(10):1767-74
pubmed: 15476944
Cell Commun Signal. 2013 Nov 11;11:86
pubmed: 24215724
Science. 2013 Sep 27;341(6153):1483-8
pubmed: 23970558
J Immunol. 2000 May 15;164(10):5362-8
pubmed: 10799899
Am J Transplant. 2019 Jun;19(6):1628-1640
pubmed: 30565852
Crit Care. 2013 Sep 10;17(5):R195
pubmed: 24020447
J Biol Chem. 2003 Mar 28;278(13):11312-9
pubmed: 12496283
Cytokine. 2010 Apr;50(1):42-9
pubmed: 20097574
FASEB J. 2012 Apr;26(4):1755-65
pubmed: 22253477
Biochem Pharmacol. 1998 Nov 1;56(9):1079-87
pubmed: 9802316
Curr Opin Pharmacol. 2002 Aug;2(4):440-4
pubmed: 12127878
Blood. 2003 Sep 15;102(6):2099-107
pubmed: 12763936
J Pharmacol Exp Ther. 2008 Feb;324(2):694-700
pubmed: 17965229
Nature. 2009 Oct 29;461(7268):1287-91
pubmed: 19865173
Life Sci. 2018 Jul 1;204:1-8
pubmed: 29733849
Neurosignals. 2009;17(1):55-70
pubmed: 19212140
Cytokine. 2012 Dec;60(3):639-45
pubmed: 22959885
Genes Cells. 2013 Jan;18(1):1-16
pubmed: 23145839
J Immunol. 2000 Jan 15;164(2):1013-9
pubmed: 10623851
J Glob Health. 2012 Jun;2(1):010404
pubmed: 23198133
Molecules. 2017 Mar 13;22(3):
pubmed: 28335409
Lab Invest. 2018 Jun;98(6):715-733
pubmed: 29467458
Eur J Anaesthesiol. 2016 May;33(5):348-55
pubmed: 26771764
Philos Trans R Soc Lond B Biol Sci. 2012 Dec 5;367(1607):3353-63
pubmed: 23108552
J Immunol. 2005 Oct 1;175(7):4383-91
pubmed: 16177079
Neurogastroenterol Motil. 2010 Mar;22(3):350-e88
pubmed: 19840270
Glia. 2010 Jul;58(9):1017-30
pubmed: 20468046
Cell Signal. 2017 Aug;36:42-55
pubmed: 28449947
Front Immunol. 2013 Apr 08;4:85
pubmed: 23580000
Thromb Haemost. 2014 Nov;112(5):876-82
pubmed: 24990498
Ann Surg. 2002 Apr;235(4):568-78
pubmed: 11923614
Psychopharmacology (Berl). 2009 Apr;203(2):329-41
pubmed: 18709360
Acta Physiol (Oxf). 2018 Jan;222(1):
pubmed: 28231640
FASEB J. 2011 Nov;25(11):3803-14
pubmed: 21784784
Sci Rep. 2017 Nov 16;7(1):15724
pubmed: 29146976
J Exp Med. 2006 Nov 27;203(12):2639-48
pubmed: 17088433
Trends Immunol. 2004 Jan;25(1):33-9
pubmed: 14698282
J Physiol. 2011 May 1;589(Pt 9):2415-31
pubmed: 21486787
Bioorg Med Chem Lett. 2016 Jan 15;26(2):241-250
pubmed: 26707396
J Immunol. 2014 Oct 1;193(7):3549-58
pubmed: 25172493
JCI Insight. 2017 Sep 7;2(17):
pubmed: 28878116
FASEB J. 2008 Oct;22(10):3491-9
pubmed: 18625677
Exp Gerontol. 2006 Nov;41(11):1165-73
pubmed: 17049787
Shock. 2017 Mar;47(3):313-317
pubmed: 27488091
Am J Pathol. 2003 Aug;163(2):711-21
pubmed: 12875990
Shock. 2008 Dec;30(6):618-22
pubmed: 18496237
J Exp Med. 2009 Jan 16;206(1):15-23
pubmed: 19103881
J Cell Sci. 2003 Dec 15;116(Pt 24):4867-9
pubmed: 14625380
Mediators Inflamm. 2013;2013:165974
pubmed: 23853427
FASEB J. 2004 Mar;18(3):537-9
pubmed: 14715696
Inflamm Res. 2019 Sep;68(9):723-726
pubmed: 31154460
Intensive Care Med. 2010 Sep;36(9):1571-8
pubmed: 20221745
Intensive Care Med. 2010 Aug;36(8):1286-98
pubmed: 20443110
Blood. 2004 Dec 15;104(13):3986-92
pubmed: 15319286
Eur J Immunol. 1998 Feb;28(2):468-72
pubmed: 9521054
Angew Chem Int Ed Engl. 2018 May 4;57(19):5292-5295
pubmed: 29469969
J Immunol. 2005 Dec 15;175(12):8260-70
pubmed: 16339566
J Leukoc Biol. 2017 Jul;102(1):95-103
pubmed: 28495790
J Trauma Acute Care Surg. 2012 Jun;72(6):1491-501
pubmed: 22695412
Nature. 2006 Nov 9;444(7116):217-20
pubmed: 17051150
Eur J Pharmacol. 2018 Sep 5;834:240-245
pubmed: 30053407
Crit Care Med. 1999 Jul;27(7):1230-51
pubmed: 10446814
Neurotherapeutics. 2017 Oct;14(4):859-873
pubmed: 28812220
Trends Pharmacol Sci. 2005 Oct;26(10):511-6
pubmed: 16125796
Anesthesiology. 2012 May;116(5):1083-91
pubmed: 22407285
Nat Rev Drug Discov. 2015 Dec;14(12):857-77
pubmed: 26493766
Neuroimmunomodulation. 2004;11(4):214-23
pubmed: 15249727
PLoS One. 2017 Sep 21;12(9):e0185132
pubmed: 28934373
Lancet. 2010 Oct 16;376(9749):1339-46
pubmed: 20934212
Heart Lung. 2007 Mar-Apr;36(2):140-7
pubmed: 17362795
Front Immunol. 2019 Jun 19;10:1371
pubmed: 31275316
Exp Cell Res. 2015 May 1;333(2):171-7
pubmed: 25499971
J Hepatol. 2017 Oct;67(4):716-726
pubmed: 28554875
J Inflamm Res. 2018 Dec 11;11:477-502
pubmed: 30588058
FASEB J. 2015 Jan;29(1):25-36
pubmed: 25318479
Mol Immunol. 2017 Oct;90:255-263
pubmed: 28846923
Thromb Haemost. 2002 Apr;87(4):722-7
pubmed: 12008957
J Biol Chem. 2002 Jan 11;277(2):1292-300
pubmed: 11694535
J Biol Chem. 2014 Dec 26;289(52):35668-84
pubmed: 25395624
J Pineal Res. 2013 Sep;55(2):103-20
pubmed: 23889107
Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1296-302
pubmed: 15155262
Methods Enzymol. 2013;520:323-35
pubmed: 23332707
Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:61-79
pubmed: 28061688
Biochem Pharmacol. 2011 Oct 1;82(7):769-77
pubmed: 21763292
Gut Microbes. 2016 May 3;7(3):189-200
pubmed: 26963409
Anesthesiology. 2015 Aug;123(2):409-22
pubmed: 26200183
Mol Pharmacol. 2016 Jan;89(1):94-104
pubmed: 26464325
J Immunol. 1999 Nov 1;163(9):4715-20
pubmed: 10528169
Crit Care Med. 2002 May;30(5 Suppl):S220-4
pubmed: 12004239
Trends Immunol. 2007 Oct;28(10):429-36
pubmed: 17845865
Nat Chem Biol. 2016 Sep;12(9):709-16
pubmed: 27398998
Pharmacol Res. 2009 Apr;59(4):221-34
pubmed: 19429463
Shock. 2018 Jun;49(6):682-689
pubmed: 29589840
FASEB J. 2007 Jun;21(8):1788-800
pubmed: 17327359
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22255-9
pubmed: 21139054
Science. 2007 Nov 23;318(5854):1266-73
pubmed: 17962519
J Exp Med. 2003 Sep 1;198(5):783-96
pubmed: 12939345
Front Endocrinol (Lausanne). 2017 Apr 25;8:76
pubmed: 28487672
J Invest Dermatol. 2019 Feb;139(2):412-421
pubmed: 30287285
J Leukoc Biol. 2007 Dec;82(6):1382-9
pubmed: 17652447
PLoS One. 2009 Jul 29;4(7):e6409
pubmed: 19641602
Trends Pharmacol Sci. 2017 Aug;38(8):701-716
pubmed: 28558960
Nat Commun. 2014 May 21;5:3944
pubmed: 24845831
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14489-94
pubmed: 9405640
J Neuroimmunol. 1995 Sep;61(2):123-31
pubmed: 7593548
Clin Exp Gastroenterol. 2015 Apr 07;8:119-30
pubmed: 25897254
Nat Rev Cancer. 2013 Dec;13(12):842-57
pubmed: 24226193
JAMA. 2019 May 28;321(20):2003-2017
pubmed: 31104070
J Biol Chem. 2007 Jun 22;282(25):18028-36
pubmed: 17452318
Pediatr Crit Care Med. 2020 May;21(5):e291-e300
pubmed: 32132499
FASEB J. 2011 Aug;25(8):2711-21
pubmed: 21551239
Thromb Res. 2014 May;133 Suppl 1:S28-31
pubmed: 24759136
Drug Des Devel Ther. 2019 Jan 30;13:491-497
pubmed: 30787591
Circ Res. 2002 Mar 22;90(5):531-8
pubmed: 11909816
PLoS One. 2014 Oct 10;9(10):e109516
pubmed: 25303226
J Immunol. 1992 Apr 1;148(7):2201-6
pubmed: 1347551
J Pharmacol Exp Ther. 2006 Apr;317(1):172-80
pubmed: 16339914
Thromb Res. 2017 Jan;149:38-44
pubmed: 27886531
Biochem Soc Trans. 2016 Apr 15;44(2):555-61
pubmed: 27068969
Lancet. 2018 Jul 7;392(10141):75-87
pubmed: 29937192
Crit Care Med. 2018 Jun;46(6):915-925
pubmed: 29537985
Ann Clin Lab Sci. 2017 Nov;47(6):729-737
pubmed: 29263047
J Immunol. 2012 Jan 1;188(1):445-53
pubmed: 22116830
J Immunol. 2016 Apr 15;196(8):3429-37
pubmed: 26969756
Gut. 2009 Aug;58(8):1135-43
pubmed: 19282305
Virulence. 2014 Jan 1;5(1):4-11
pubmed: 24335434
Cancer Res. 2009 Apr 1;69(7):2826-32
pubmed: 19276343
J Immunol. 1985 Aug;135(2):1366-71
pubmed: 2989364
Trends Immunol. 2009 Jun;30(6):263-70
pubmed: 19427267
Mol Endocrinol. 2011 Nov;25(11):1835-48
pubmed: 21964594
Circulation. 2006 Mar 7;113(9):1244-54
pubmed: 16505172
Adv Pharmacol. 2011;62:279-314
pubmed: 21907913
J Leukoc Biol. 2013 Dec;94(6):1309-15
pubmed: 23922379
FEBS Lett. 2015 Jul 8;589(15):1832-9
pubmed: 26071379
Nature. 2001 Dec 20-27;414(6866):916-20
pubmed: 11780065
Clin Pharmacokinet. 2007;46(9):757-66
pubmed: 17713973
Nature. 2009 Oct 29;461(7268):1282-6
pubmed: 19865172
Immunology. 1997 Jan;90(1):95-100
pubmed: 9038718
Crit Care Med. 2012 Mar;40(3):770-7
pubmed: 22080632
J Immunol. 2006 Dec 1;177(11):7531-9
pubmed: 17114422
Sci Transl Med. 2016 Aug 24;8(353):353ra111
pubmed: 27559094
J Biol Chem. 2016 Oct 28;291(44):23188-23198
pubmed: 27613872
Data Brief. 2016 Jun 01;8:411-4
pubmed: 27366778
Int J Mol Sci. 2013 Apr 22;14(4):8638-83
pubmed: 23609496
Trends Immunol. 2017 Dec;38(12):927-941
pubmed: 28935522
Front Immunol. 2018 Sep 13;9:2079
pubmed: 30271409
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5088-97
pubmed: 24309376
FASEB J. 1998 Aug;12(11):1035-44
pubmed: 9707176
J Pharmacol Exp Ther. 2015 Jan;352(1):61-6
pubmed: 25355645
Neuroscience. 1995 Oct;68(4):1263-76
pubmed: 8544999
Nat Rev Immunol. 2005 May;5(5):400-11
pubmed: 15864274
Pharmacol Rev. 2014 Jul;66(3):598-637
pubmed: 24928328
Circ Res. 2003 Feb 21;92(3):272-8
pubmed: 12595338
Shock. 2014 May;41(5):406-12
pubmed: 24430540
Clin Hemorheol Microcirc. 2018;70(4):553-561
pubmed: 30347614
Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2280-8
pubmed: 15604130
Cardiovasc Drugs Ther. 2016 Dec;30(6):551-558
pubmed: 27757725
Nature. 2017 Aug 24;548(7668):480-484
pubmed: 28813418
J Immunol. 2017 Jan 15;198(2):842-851
pubmed: 27994074
Mol Pharmacol. 2014 Mar;85(3):472-81
pubmed: 24319111
Crit Care Med. 2017 Jan;45(1):58-68
pubmed: 27632672
J Clin Invest. 2006 Feb;116(2):304-6
pubmed: 16453017
Ann Surg. 2016 Aug;264(2):392-8
pubmed: 26727083
Nat Rev Cardiol. 2018 Mar;15(3):151-166
pubmed: 28905873
Adv Immunol. 1985;37:217-67
pubmed: 3159188
Mol Immunol. 2008 Apr;45(8):2247-54
pubmed: 18178251
J Med Chem. 2010 Apr 8;53(7):2695-708
pubmed: 20043680
Nat Med. 2005 Jun;11(6):661-5
pubmed: 15880119
Immunity. 2016 Jan 19;44(1):59-72
pubmed: 26789922
Pharmacol Ther. 2003 Jul;99(1):25-44
pubmed: 12804697
New Horiz. 1996 May;4(2):252-64
pubmed: 8774800
Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7440-5
pubmed: 10861009
Crit Care Med. 2001 Jul;29(7 Suppl):S28-34; discussion S34-5
pubmed: 11445731
Lancet Infect Dis. 2008 Jan;8(1):32-43
pubmed: 18063412
Prog Cardiovasc Dis. 2012 May-Jun;54(6):503-11
pubmed: 22687592
Ann Surg. 1991 Mar;213(3):261-4
pubmed: 1998407
Immunol Lett. 1996 Mar;49(3):143-7
pubmed: 8739308
Biochim Biophys Acta. 2013 Aug;1833(8):1914-23
pubmed: 23562731
Front Pharmacol. 2019 Feb 19;10:125
pubmed: 30837883
Crit Care. 2010;14(3):R94
pubmed: 20500817
J Leukoc Biol. 2008 Mar;83(3):447-55
pubmed: 18160539
Aging (Albany NY). 2016 Jan;8(1):178-91
pubmed: 26837433
Pharmacol Rev. 2013 Sep 24;65(4):1198-213
pubmed: 24064459
Neurosignals. 2003 Jan-Feb;12(1):1-12
pubmed: 12624524
Immunol Cell Biol. 2015 Apr;93(4):372-83
pubmed: 25708536
Nature. 1999 Sep 16;401(6750):282-6
pubmed: 10499587
Nature. 2009 May 21;459(7245):356-63
pubmed: 19458711
JAMA. 2017 Apr 11;317(14):1433-1442
pubmed: 28322415
Placenta. 2009 Jul;30(7):579-84
pubmed: 19428101
Front Pharmacol. 2018 May 23;9:533
pubmed: 29875665
J Immunol. 2002 Apr 1;168(7):3557-62
pubmed: 11907119
Pharmacol Rev. 2013 Nov 11;66(1):1-79
pubmed: 24218476
Crit Care Med. 2012 Mar;40(3):725-30
pubmed: 22036860
Mol Pharmacol. 2003 Jun;63(6):1256-72
pubmed: 12761335
Br J Pharmacol. 2008 Jan;153(2):252-62
pubmed: 18026124
JAMA. 2011 Dec 21;306(23):2594-605
pubmed: 22187279
J Immunol. 2011 Oct 15;187(8):4256-67
pubmed: 21918191
Methods Mol Biol. 2015;1324:191-203
pubmed: 26202271
Intensive Care Med. 2017 Mar;43(3):304-377
pubmed: 28101605
Front Pharmacol. 2010 Dec 31;1:144
pubmed: 21833183
Shock. 2016 Mar;45(3):259-70
pubmed: 26871664
EMBO Mol Med. 2011 Jul;3(7):370-84
pubmed: 21591259
Nat Immunol. 2007 Dec;8(12):1303-12
pubmed: 17965715
PLoS One. 2014 Jun 11;9(2):e98819
pubmed: 24919177
J Immunol. 2018 Apr 15;200(8):2905-2914
pubmed: 29514953
Adv Pharmacol. 2017;80:169-206
pubmed: 28826534
Curr Opin Pharmacol. 2012 Dec;12(6):653-8
pubmed: 23063456
J Biol Chem. 2010 Jan 29;285(5):3451-61
pubmed: 19906641
Handb Exp Pharmacol. 2017;238:105-122
pubmed: 27885524
Curr Opin Cell Biol. 2014 Apr;27:25-31
pubmed: 24680427
Blood. 2007 Oct 1;110(7):2685-95
pubmed: 17525287
Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1224-H1237
pubmed: 28455289
Am J Respir Crit Care Med. 2000 Jun;161(6):1781-5
pubmed: 10852744
PLoS One. 2018 Jul 27;13(7):e0201139
pubmed: 30052667
Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2210-8
pubmed: 17660390
FASEB J. 2015 Sep;29(9):3863-75
pubmed: 26045547
J Cardiovasc Pharmacol Ther. 2016 Jan;21(1):100-13
pubmed: 26025460
FASEB J. 2010 Aug;24(8):2631-40
pubmed: 20371613
Crit Care. 2009;13(5):230
pubmed: 19863760
Neurochem Int. 2009 Dec;55(7):447-53
pubmed: 19477210
Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16937-42
pubmed: 25385614
J Am Soc Nephrol. 2016 Mar;27(3):792-803
pubmed: 26160897
Immunol Res. 1987;6(3):192-209
pubmed: 2960763
Biochim Biophys Acta. 2015 Apr;1851(4):397-413
pubmed: 25139562
Immunol Lett. 2012 Jul 30;145(1-2):15-22
pubmed: 22698179
Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):619-24
pubmed: 24100676
Intensive Care Med. 1996 Jul;22(7):707-10
pubmed: 8844239
Curr Pharm Des. 2014;20(38):6028-36
pubmed: 24641233
Shock. 2013 Aug;40(2):129-35
pubmed: 23698550
FASEB J. 2013 Mar;27(3):855-64
pubmed: 23239822
Shock. 2013 Jan;39(1):113-4
pubmed: 23247128
Neurochem Res. 2001 Sep;26(8-9):1039-44
pubmed: 11699931
Cell Mol Life Sci. 2017 Nov;74(21):3965-3987
pubmed: 28785808
Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1368-1380
pubmed: 29622563
Shock. 2009 Dec;32(6):614-20
pubmed: 19295473
J Pineal Res. 2007 Nov;43(4):365-71
pubmed: 17910605
J Clin Invest. 1988 Aug;82(2):640-51
pubmed: 2969921
Aging Cell. 2014 Aug;13(4):690-8
pubmed: 24779584
J Basic Clin Physiol Pharmacol. 2016 May 1;27(3):297-302
pubmed: 26669245
Circulation. 2012 Jul 3;126(1):83-91
pubmed: 22705889
J Exp Med. 1998 Oct 19;188(8):1433-43
pubmed: 9782120
J Immunol. 1997 Jul 15;159(2):976-82
pubmed: 9218619
Br J Pharmacol. 2010 Jul;160(5):1048-61
pubmed: 20590599
Biochem Biophys Res Commun. 2003 Apr 18;303(4):1047-52
pubmed: 12684041
Naunyn Schmiedebergs Arch Pharmacol. 1993 Jul;348(1):108-12
pubmed: 8377834
Free Radic Biol Med. 2011 Jan 1;50(1):179-95
pubmed: 21070851
Inflammation. 2019 Apr;42(2):618-627
pubmed: 30556096
Neurogastroenterol Motil. 2011 Sep;23(9):862-e342
pubmed: 21726355
Drug Discov Today. 2014 Aug;19(8):1145-51
pubmed: 24370891
Gastroenterology. 2013 Apr;144(4):808-817.e15
pubmed: 23295443
J Immunol. 1998 Sep 1;161(5):2600-8
pubmed: 9725262
Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700):
pubmed: 27377730
Immunity. 2014 Jan 16;40(1):128-39
pubmed: 24412617
Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72
pubmed: 26414292
J Neuroimmunol. 2000 Nov 1;111(1-2):45-54
pubmed: 11063820
Lancet Respir Med. 2017 Oct;5(10):816-826
pubmed: 28864056
Inflammation. 2013 Aug;36(4):921-31
pubmed: 23504259
Eur J Pharmacol. 1998 Oct 9;358(3):261-8
pubmed: 9822893
Pharmacol Ther. 2007 Feb;113(2):264-75
pubmed: 17056121
Nat Struct Mol Biol. 2018 Jun;25(6):472-481
pubmed: 29867214
J Neuroimmunol. 1998 Aug 1;88(1-2):57-61
pubmed: 9688324
Shock. 2014 Nov;42(5):383-91
pubmed: 25051284
J Pept Sci. 2013 Nov;19(11):717-24
pubmed: 24133031
Blood. 2003 May 15;101(10):3985-90
pubmed: 12446452
PLoS One. 2013 May 31;8(5):e65561
pubmed: 23741498
ACS Pharmacol Transl Sci. 2018 Sep 07;1(2):73-83
pubmed: 32219204
Blood. 2004 Feb 15;103(4):1391-7
pubmed: 14551144
Am J Physiol. 1996 Feb;270(2 Pt 1):C522-9
pubmed: 8779915
Immunobiology. 2012 Nov;217(11):1067-79
pubmed: 22964232
Blood. 2012 Feb 16;119(7):1717-25
pubmed: 22186993
Blood. 2016 Oct 6;128(14):1884-1893
pubmed: 27561318
Shock. 2020 Jul;54(1):87-95
pubmed: 31318833
Pharmacology. 2018;102(5-6):339-346
pubmed: 30384375
Br J Pharmacol. 2005 Dec;146(7):1019-26
pubmed: 16231007
Trends Mol Med. 2013 Jun;19(6):355-67
pubmed: 23601906
J Exp Med. 1991 Jan 1;173(1):55-64
pubmed: 1702139
Nat Rev Drug Discov. 2008 Sep;7(9):759-70
pubmed: 18758473
Curr Opin Crit Care. 2011 Oct;17(5):480-6
pubmed: 21900767
Expert Opin Investig Drugs. 2011 Jun;20(6):757-68
pubmed: 21457061
J Pharmacol Exp Ther. 2000 Apr;293(1):136-50
pubmed: 10734163
Nat Med. 2008 May;14(5):551-7
pubmed: 18454156
J Immunol. 2011 Feb 15;186(4):2444-53
pubmed: 21242513