Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
28
09
2019
accepted:
16
01
2020
entrez:
22
3
2020
pubmed:
22
3
2020
medline:
4
8
2020
Statut:
ppublish
Résumé
Diabetes is now a pandemic disease. Moreover, a large number of people with prediabetes are at risk for developing frank diabetes worldwide. Both type 1 and type 2 diabetes increase the risk of atherosclerotic cardiovascular disease (CVD). Even with statin treatment to lower LDL cholesterol, patients with diabetes have a high residual CVD risk. Factors mediating the residual risk are incompletely characterized. An attractive hypothesis is that remnant lipoprotein particles (RLPs), derived by lipolysis from VLDL and chylomicrons, contribute to this residual risk. RLPs constitute a heterogeneous population of lipoprotein particles, varying markedly in size and composition. Although a universally accepted definition is lacking, for the purpose of this review we define RLPs as postlipolytic partially triglyceride-depleted particles derived from chylomicrons and VLDL that are relatively enriched in cholesteryl esters and apolipoprotein (apo)E. RLPs derived from chylomicrons contain apoB48, while those derived from VLDL contain apoB100. Clarity as to the role of RLPs in CVD risk is hampered by lack of a widely accepted definition and a paucity of adequate methods for their accurate and precise quantification. New specific methods for RLP quantification would greatly improve our understanding of their biology and role in promoting atherosclerosis in diabetes and other disorders.
Identifiants
pubmed: 32198194
pii: 69/4/508
doi: 10.2337/dbi19-0007
pmc: PMC7085249
doi:
Substances chimiques
Chylomicrons
0
Lipoproteins
0
Lipoproteins, VLDL
0
Triglycerides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
508-516Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL144558
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126028
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK108209
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127694
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : NIDDK NIH HHS
ID : P60 DK020541
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL092969
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL073029
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL045095
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL128203
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135833
Pays : United States
Informations de copyright
© 2020 by the American Diabetes Association.
Références
Lancet. 1987 Jul 11;2(8550):62-6
pubmed: 2885572
J Clin Invest. 2019 Jul 11;130:4165-4179
pubmed: 31295146
Clin Cardiol. 1999 Jun;22(6 Suppl):II21-7
pubmed: 10376193
Klin Wochenschr. 1977 Nov 1;55(21):1025-30
pubmed: 200792
Lancet Diabetes Endocrinol. 2018 May;6(5):361-369
pubmed: 29503172
J Atheroscler Thromb. 1994;1(2):98-102
pubmed: 9222876
Atherosclerosis. 2019 Jul;286:97-104
pubmed: 31108411
Atherosclerosis. 2007 May;192(1):138-47
pubmed: 16740268
J Lipid Res. 1992 Mar;33(3):369-80
pubmed: 1569386
J Clin Invest. 2009 Nov;119(11):3236-45
pubmed: 19805913
Diabetes Care. 1991 Sep;14(9):839-55
pubmed: 1959476
Clin Endocrinol (Oxf). 2003 Apr;58(4):415-20
pubmed: 12641623
Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):191-204
pubmed: 27908890
J Clin Invest. 1973 Jan;52(1):32-8
pubmed: 4345202
Clin Chem. 2017 Aug;63(8):1418-1419
pubmed: 28606912
JAMA. 2007 Jul 18;298(3):299-308
pubmed: 17635890
Nutrients. 2013 Mar 22;5(3):981-1001
pubmed: 23525082
Endocr Pract. 2017 Jan;23(1):100-112
pubmed: 27819772
Vasc Health Risk Manag. 2016 May 06;12:171-83
pubmed: 27226718
Clin Chem. 2009 Nov;55(11):2061-2; author reply 2062-3
pubmed: 19762450
J Clin Invest. 1979 Jul;64(1):162-71
pubmed: 221542
J Clin Invest. 1991 Sep;88(3):985-94
pubmed: 1885783
Eur Heart J. 2011 Jun;32(11):1345-61
pubmed: 21531743
Science. 2008 Dec 12;322(5908):1702-5
pubmed: 19074352
Arterioscler Thromb Vasc Biol. 1997 Sep;17(9):1707-15
pubmed: 9327767
Atherosclerosis. 2015 May;240(1):90-7
pubmed: 25768710
Clin Chim Acta. 2017 Feb;465:45-52
pubmed: 27986550
Diabetes. 1992 Mar;41(3):325-33
pubmed: 1551492
Clin Chem. 1998 Dec;44(12):2490-8
pubmed: 9836716
Diabetes. 1986 Aug;35(8):933-42
pubmed: 3732634
J Intern Med. 1991 Aug;230(2):183-6
pubmed: 1865171
Clin Chem. 2007 Dec;53(12):2128-35
pubmed: 17901111
J Am Coll Cardiol. 2017 Feb 21;69(7):789-800
pubmed: 28209220
Atherosclerosis. 2009 May;204(1):105-11
pubmed: 18834984
Atherosclerosis. 2016 Mar;246:187-92
pubmed: 26800308
Metabolism. 1977 May;26(5):493-503
pubmed: 139529
Ann Intern Med. 1975 Feb;82(2):158-74
pubmed: 163608
J Biol Chem. 1985 Jul 25;260(15):8783-8
pubmed: 2991220
Lancet. 1977 Jun 4;1(8023):1176-8
pubmed: 68276
Lancet. 2008 May 24;371(9626):1800-9
pubmed: 18502305
Diabetes. 2016 Jul;65(7):1767-78
pubmed: 27329952
Clin Chem. 2008 Aug;54(8):1307-16
pubmed: 18515257
J Clin Invest. 1975 Sep;56(3):603-15
pubmed: 169294
Curr Opin Endocrinol Diabetes Obes. 2017 Apr;24(2):133-139
pubmed: 28098593
J Am Coll Cardiol. 2008 Jul 22;52(4):255-62
pubmed: 18634979
Diabetes Care. 2014 Oct;37(10):2843-63
pubmed: 25114297
Diabetes Metab. 2009 Nov;35(5):353-60
pubmed: 19733492
Endocr Rev. 2019 Apr 1;40(2):537-557
pubmed: 30312399
J Clin Invest. 1970 Oct;49(10):1853-8
pubmed: 5460288
Circulation. 2011 May 24;123(20):2292-333
pubmed: 21502576
Atherosclerosis. 2000 Apr;149(2):315-22
pubmed: 10729381
J Lipid Res. 2019 Aug;60(8):1432-1439
pubmed: 31203233
Adv Clin Chem. 2014;64:117-77
pubmed: 24938018
J Clin Invest. 2016 Aug 1;126(8):2855-66
pubmed: 27400128
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2069-73
pubmed: 8446630
Trends Endocrinol Metab. 2013 Aug;24(8):391-7
pubmed: 23721961
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):236-46
pubmed: 22155452
Arteriosclerosis. 1986 Jan-Feb;6(1):79-87
pubmed: 3942562
N Engl J Med. 2019 Jan 3;380(1):11-22
pubmed: 30415628
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):459-66
pubmed: 22095987
Circ Res. 1973 Dec;33(6):633-8
pubmed: 4361710
Lancet. 2010 Jun 26;375(9733):2215-22
pubmed: 20609967
J Clin Invest. 1973 Jul;52(7):1533-43
pubmed: 4718952
J Diabetes Complications. 2002 Jan-Feb;16(1):29-34
pubmed: 11872363
Clin Chem. 2014 Nov;60(11):1393-401
pubmed: 25225166
Metabolism. 1978 Sep;27(9):1055-66
pubmed: 210351
Diabetologia. 2015 May;58(5):886-99
pubmed: 25725623
Circulation. 1979 Sep;60(3):473-85
pubmed: 222498