Autoimmunity in Acute Myocarditis: How Immunopathogenesis Steers New Directions for Diagnosis and Treatment.
Autoimmunity
Immune checkpoint inhibitors
Myocarditis
Journal
Current cardiology reports
ISSN: 1534-3170
Titre abrégé: Curr Cardiol Rep
Pays: United States
ID NLM: 100888969
Informations de publication
Date de publication:
20 03 2020
20 03 2020
Historique:
entrez:
22
3
2020
pubmed:
22
3
2020
medline:
21
10
2020
Statut:
epublish
Résumé
Over the last decade, myocarditis has been increasingly recognized as common cause of sudden cardiac death in young adults and heart failure overall. The purpose of this review is to discuss hypothesis of development of non-infectious myocarditis, to provide a description of the immunopathogenesis and the most common mechanisms of autoimmunity in myocarditis, and to provide an update on therapeutic options. A new entity of myocarditis is immune checkpoint inhibitor (ICI) induced myocarditis. ICIs are used in advanced cancer to "disinhibit" the immune system and make it more aggressive in fighting cancer. This novel drug class has doubled life expectancy in metastatic melanoma and significantly increased progression free survival in advanced non-small-cell lung cancer, but comes with a risk of autoimmune diseases such as myocarditis resulting from an overly aggressive immune system. Myocarditis is an inflammatory disease of the heart with major public health impact. Thorough understanding of its immunopathogenesis is crucial for accurate diagnosis and effective treatment.
Identifiants
pubmed: 32198622
doi: 10.1007/s11886-020-01278-1
pii: 10.1007/s11886-020-01278-1
pmc: PMC7083821
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
28Références
J Immunol. 2012 May 15;188(10):4876-84
pubmed: 22491251
Circulation. 1994 Jan;89(1):252-7
pubmed: 8281654
J Am Coll Cardiol. 2018 Apr 24;71(16):1755-1764
pubmed: 29567210
Circulation. 2001 Dec 18;104(25):3145-51
pubmed: 11748115
Sci Rep. 2016 Mar 02;6:22613
pubmed: 26931072
J Am Coll Cardiol. 2000 May;35(6):1590-8
pubmed: 10807465
Circulation. 1997 Jun 3;95(11):2476-8
pubmed: 9184576
J Am Coll Cardiol. 2003 Aug 6;42(3):466-72
pubmed: 12906974
J Exp Med. 2006 Aug 7;203(8):2009-19
pubmed: 16880257
J Immunol. 2007 Jun 1;178(11):6710-4
pubmed: 17513715
Heart. 2010 May;96(10):765-71
pubmed: 20448127
Curr Cardiol Rep. 2017 Mar;19(3):21
pubmed: 28220466
J Immunother Cancer. 2016 Aug 16;4:50
pubmed: 27532025
Am J Cardiol. 1994 Sep 1;74(5):510-2
pubmed: 8059740
J Mol Med (Berl). 2016 Sep;94(9):1063-79
pubmed: 27052830
Am J Cardiol. 2019 Jul 1;124(1):131-136
pubmed: 31060730
Hum Pathol. 1992 Feb;23(2):138-43
pubmed: 1740298
J Mol Cell Cardiol. 2010 Jun;48(6):1236-44
pubmed: 20211628
Oncotarget. 2017 Nov 21;8(63):106165-106166
pubmed: 29290934
Front Cardiovasc Med. 2019 May 16;6:64
pubmed: 31157241
Cardiovasc Res. 2006 Dec 1;72(3):384-93
pubmed: 17054926
Circulation. 1999 Feb 23;99(7):889-95
pubmed: 10027811
Am J Physiol. 1999 Jul;277(1):H253-60
pubmed: 10409204
Eur Heart J. 2017 May 7;38(18):1413-1425
pubmed: 27099262
ESMO Open. 2017 Oct 26;2(4):e000247
pubmed: 29104763
Circ Res. 2015 Jan 16;116(2):354-67
pubmed: 25593279
Immunobiology. 2012 May;217(5):468-75
pubmed: 21820754
N Engl J Med. 2016 Nov 03;375(18):1749-1755
pubmed: 27806233
Scand J Immunol. 2010 Apr;71(4):298-303
pubmed: 20384874
Circulation. 2011 Mar 22;123(11):1174-84
pubmed: 21382894
Eur J Immunol. 2016 Jan;46(1):22-33
pubmed: 26450177
Br J Pharmacol. 2017 Nov;174(22):3914-3925
pubmed: 27590129
Circulation. 1991 Feb;83(2):515-22
pubmed: 1825038
Trends Cardiovasc Med. 2012 Jul;22(5):113-7
pubmed: 22902177
Circulation. 2001 Jul 3;104(1):39-45
pubmed: 11435335
Trends Immunol. 2017 Nov;38(11):829-843
pubmed: 28826941
Am J Pathol. 2008 May;172(5):1195-208
pubmed: 18403598
Eur Heart J. 2015 Jun 14;36(23):1434-6
pubmed: 25157113
Intern Med. 2003 Jan;42(1):3-6
pubmed: 12583610
Int Med Case Rep J. 2017 Jul 10;10:229-231
pubmed: 28744164
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
N Engl J Med. 2015 Sep 3;373(10):929-38
pubmed: 26332547
Front Immunol. 2018 Jan 15;8:1844
pubmed: 29379498
Nature. 2011 Jan 20;469(7330):336-42
pubmed: 21248840
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16029-34
pubmed: 25349429
Am J Pathol. 2001 Jul;159(1):193-203
pubmed: 11438466
Am J Pathol. 1991 Mar;138(3):721-6
pubmed: 1848043
Circulation. 2005 Nov 29;112(22):3400-7
pubmed: 16316965
J Autoimmun. 2003 Jun;20(4):345-50
pubmed: 12791320
Eur J Immunol. 2012 Mar;42(3):726-36
pubmed: 22161142
J Clin Psychopharmacol. 2019 Jul/Aug;39(4):380-385
pubmed: 31205188
Circ Res. 2012 Aug 3;111(4):415-25
pubmed: 22715471
Am J Pathol. 2015 Mar;185(3):847-61
pubmed: 25622543
Circ Heart Fail. 2018 Feb;11(2):e004228
pubmed: 29449368
Eur Heart J. 2011 Nov;32(21):2616-25
pubmed: 21705357
J Card Fail. 2019 Jun;25(6):457-467
pubmed: 31035007
Nat Rev Immunol. 2015 Feb;15(2):117-29
pubmed: 25614321
Hum Immunol. 1992 Nov;35(3):193-9
pubmed: 1293083
Molecules. 2017 Jan 14;22(1):
pubmed: 28098832
Cancer Immunol Res. 2018 Sep;6(9):1039-1045
pubmed: 30002157
Pediatr Cardiol. 2007 Jan-Feb;28(1):21-6
pubmed: 17165111
Cardiovasc Res. 2007 Jul 1;75(1):158-67
pubmed: 17434153
Clin Exp Immunol. 2012 Aug;169(2):79-88
pubmed: 22774982
Front Immunol. 2018 Jan 31;9:57
pubmed: 29445371
Br Heart J. 1972 Jun;34(6):575-83
pubmed: 5051314
Br J Cancer. 2017 Sep 26;117(7):921-924
pubmed: 28797029
Heart Lung Circ. 2012 Dec;21(12):787-93
pubmed: 22901461
Front Biosci. 2008 Jan 01;13:453-61
pubmed: 17981560
JCI Insight. 2016 Jun 16;1(9):
pubmed: 27366791
Blood. 2011 Nov 17;118(20):5671-80
pubmed: 21948174
Transpl Immunol. 2004 Sep-Oct;13(2):117-30
pubmed: 15380542
Eur Heart J. 2009 Aug;30(16):1995-2002
pubmed: 19556262
Circ Cardiovasc Genet. 2010 Dec;3(6):499-506
pubmed: 20921333
Circ Res. 2008 Oct 24;103(9):919-28
pubmed: 18948630
J Am Coll Cardiol. 2016 Nov 29;68(21):2348-2364
pubmed: 27884253
Circulation. 2003 Feb 18;107(6):857-63
pubmed: 12591756
Front Immunol. 2019 Jan 31;10:43
pubmed: 30804926
Am J Transplant. 2019 Aug;19(8):2186-2198
pubmed: 30768842
N Engl J Med. 1989 Oct 19;321(16):1061-8
pubmed: 2677721
Circulation. 2001 May 8;103(18):2254-9
pubmed: 11342473
Eur J Immunol. 2010 Jul;40(7):1830-5
pubmed: 20583029
N Engl J Med. 1995 Aug 3;333(5):269-75
pubmed: 7596370
Swiss Med Wkly. 2019 Jul 03;149:w20098
pubmed: 31269222
Eur J Cancer. 2019 Jan;107:8-14
pubmed: 30529903
Circ Res. 2009 Aug 28;105(5):462-70
pubmed: 19628793
J Immunol. 2016 Sep 15;197(6):2045-50
pubmed: 27591335
Eur Heart J. 2015 Nov 7;36(42):2909-19
pubmed: 26206211
Nat Biotechnol. 2019 Mar;37(3):238-251
pubmed: 30804535
Nat Immunol. 2010 Oct;11(10):889-96
pubmed: 20856220
J Immunol. 2008 Feb 15;180(4):2686-95
pubmed: 18250481
J Am Coll Cardiol. 2018 Oct 30;72(18):2213-2230
pubmed: 30360829
Eur Heart J. 2015 Jun 14;36(23):1478-88
pubmed: 24950695
Sci Transl Med. 2015 Jan 28;7(272):272ra10
pubmed: 25632034
J Immunol. 2013 Oct 15;191(8):4038-47
pubmed: 24048893
Eur Heart J. 2013 Sep;34(33):2636-48, 2648a-2648d
pubmed: 23824828
Heart Lung Circ. 2016 Apr;25(4):325-32
pubmed: 26706652
J Immunother Cancer. 2016 Mar 15;4:13
pubmed: 26981243
Am J Cardiol. 2015 Jun 15;115(12):1733-8
pubmed: 25882774
JACC Heart Fail. 2018 Jul;6(7):573-579
pubmed: 29885953
Lancet Oncol. 2018 Dec;19(12):1579-1589
pubmed: 30442497
Cardiovasc Res. 2014 Feb 1;101(2):203-10
pubmed: 24189626