Ongoing Developments and Clinical Progress in Drug-Loaded Red Blood Cell Technologies.
Journal
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy
ISSN: 1179-190X
Titre abrégé: BioDrugs
Pays: New Zealand
ID NLM: 9705305
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
pubmed:
22
3
2020
medline:
27
1
2021
entrez:
22
3
2020
Statut:
ppublish
Résumé
Engineered red blood cells (RBCs) appear to be a promising method for therapeutic drug and protein delivery. With a number of agents in clinical trials (e.g., dexamethasone 21-phosphate in ataxia telangiectasia, asparaginase in pancreatic cancer/acute lymphoblastic leukemia, thymidine phosphorylase in mitochondrial neurogastrointestinal encephalomyopathy, RTX-134 in phenylketonuria, etc.), this leading article summarizes the ongoing efforts in developing these agents, focuses on the clinical progress, and provides a brief background into engineered RBCs and the different ways in which they can be exploited for therapeutic/diagnostic purposes. References to available data on safety, efficacy, and tolerability are reported. Due to the continuous progress in this field, the information is updated as of January 2020 from databases, websites, and press releases of the involved companies and information that is in the public domain.
Identifiants
pubmed: 32198632
doi: 10.1007/s40259-020-00415-0
pii: 10.1007/s40259-020-00415-0
pmc: PMC7211199
doi:
Substances chimiques
Drug Carriers
0
Dexamethasone
7S5I7G3JQL
Thymidine Phosphorylase
EC 2.4.2.4
Asparaginase
EC 3.5.1.1
Phenylalanine Ammonia-Lyase
EC 4.3.1.24
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
265-272Subventions
Organisme : Horizon 2020
ID : grant n. 667946
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