The zebrafish Znt1a

Amino Acids / genetics Animals Carrier Proteins / genetics Embryonic Development / genetics Homeostasis / genetics Mutation Zebrafish Zebrafish Proteins / genetics Zinc / metabolism
Development ERK1/2 Slc30a1 Zebrafish Zinc

Journal

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 11 11 2019
revised: 18 02 2020
accepted: 06 03 2020
pubmed: 22 3 2020
medline: 26 1 2021
entrez: 22 3 2020
Statut: ppublish

Résumé

Zinc is one of the vital micronutrients required through various developmental stages in animals. Zinc transporter-1 (ZnT1; Slc30a1) is essential in vertebrates for nutritional zinc uptake and cellular zinc extrusion. Knockout of ZnT1 is lethal in vertebrates and there are therefore few functional studies of this protein in vivo. In the present study we characterised the embryonic development in a zebrafish Znt1a mutant (Znt1a The homozygous Znt1a This study is the first to show that the last 40 amino acids of Znt1a are of importance for its role in zinc homeostasis and ability to activate the MAPK/ERK pathway contrary to what was previously thought.

Sections du résumé

BACKGROUND BACKGROUND
Zinc is one of the vital micronutrients required through various developmental stages in animals. Zinc transporter-1 (ZnT1; Slc30a1) is essential in vertebrates for nutritional zinc uptake and cellular zinc extrusion. Knockout of ZnT1 is lethal in vertebrates and there are therefore few functional studies of this protein in vivo.
METHODS METHODS
In the present study we characterised the embryonic development in a zebrafish Znt1a mutant (Znt1a
RESULTS RESULTS
The homozygous Znt1a
CONCLUSION CONCLUSIONS
This study is the first to show that the last 40 amino acids of Znt1a are of importance for its role in zinc homeostasis and ability to activate the MAPK/ERK pathway contrary to what was previously thought.

Identifiants

DOI: 10.1016/j.jtemb.2020.126496 PMID: 32199393
pubmed: 32199393
pii: S0946-672X(20)30061-4
doi: 10.1016/j.jtemb.2020.126496
pii:
doi:

Substances chimiques

Amino Acids 0
Carrier Proteins 0
Zebrafish Proteins 0
zinc-binding protein 0
Zinc J41CSQ7QDS

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

126496

Informations de copyright

Copyright © 2020 Elsevier GmbH. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors have no conflict of interest.

Auteurs

Issa A Muraina (IA)

King's College London, Department of Nutritional Sciences, School of Life Course Sciences, Metal Metabolism Group, London, UK.

Nic R Bury (NR)

King's College London, Department of Nutritional Sciences, School of Life Course Sciences, Metal Metabolism Group, London, UK.

Annabella Scott (A)

Kings College London, Centre for Developmental Neurobiology, London, UK.

Anthony Graham (A)

Kings College London, Centre for Developmental Neurobiology, London, UK.

Christer Hogstrand (C)

King's College London, Department of Nutritional Sciences, School of Life Course Sciences, Metal Metabolism Group, London, UK. Electronic address: christer.hogstrand@kcl.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › The zebrafish Znt1a
questionsmedicales.fr › Eucaryotes › Animaux › The zebrafish Znt1a
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › The zebrafish Znt1a
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › The zebrafish Znt1a
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › The zebrafish Znt1a
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › The zebrafish Znt1a
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › The zebrafish Znt1a
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › The zebrafish Znt1a
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zinc › The zebrafish Znt1a