Natriuretic peptides for heart failure screening in nursing homes: a systematic review.
Elderly
Heart failure
Natriuretic peptides
Nursing home
Screening
Journal
Heart failure reviews
ISSN: 1573-7322
Titre abrégé: Heart Fail Rev
Pays: United States
ID NLM: 9612481
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
23
3
2020
medline:
15
12
2021
entrez:
23
3
2020
Statut:
ppublish
Résumé
The high burden of heart failure in nursing-home populations is due to advanced age and comorbidities. Heart failure is often undiagnosed or misdiagnosed in this population and therefore remains untreated. We review the use of natriuretic peptide biomarkers for screening heart failure in nursing-home residents. The study was performed in accordance with recommendations from the Cochrane Collaboration using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA) and is registered in PROSPERO Register of Systematic Reviews. Databases PubMed, Embase, and Trip were searched from 2000 to March 2019, supplemented by hand-searching of references. Studies investigating the nursing-home population were included. The prevalence of heart failure among nursing-home residents was higher than in the general population of comparable age (23% vs 10%, respectively). The rate of misdiagnosis in nursing homes ranged from 25 to 76%. NT-proBNP was the most commonly used natriuretic peptide biomarker for heart failure screening. The mean value of NT-proBNP was significantly higher in residents with heart failure than in residents overall (pooled means of 2409 pg/mL vs 1074 pg/mL, respectively). In comparison with current guidelines, the proposed cut-off values for ruling out heart failure were higher in the analyzed studies, with ranges of 230-760 pg/mL for NT-proBNP and 50-115 pg/mL for BNP. NT-proBNP and BNP are used for screening heart failure in the nursing-home population. The current screening cut-off values are probably too low for use in nursing homes. Our most conservative estimation for ruling out heart failure is an NT-proBNP cut-off value of 230 pg/mL.
Identifiants
pubmed: 32200491
doi: 10.1007/s10741-020-09944-w
pii: 10.1007/s10741-020-09944-w
doi:
Substances chimiques
Biomarkers
0
Natriuretic Peptides
0
Peptide Fragments
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1131-1140Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
Références
James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N et al (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159):1789–1858
doi: 10.1016/S0140-6736(18)32279-7
Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP et al (2018) Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet 391(10120):572–580
doi: 10.1016/S0140-6736(17)32520-5
Mosterd A, Hoes AW (2007) Clinical epidemiology of heart failure. Heart 93:1137–1146
doi: 10.1136/hrt.2003.025270
Bleumink GS, Knetsch AM, Sturkenboom MC, Straus SM, Hofman A, Deckers JW et al (2004) Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure: The Rotterdam Study. Eur Heart J 25:1614–1619
doi: 10.1016/j.ehj.2004.06.038
Pocock SJ, Ariti CA, McMurray JJ, Maggioni A, Køber L, Squire IB et al (2012) Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies. Eur Heart J 34:1404–1413
doi: 10.1093/eurheartj/ehs337
Maggioni AP, Anker SD, Dahlström U, Filippatos G, Ponikowski P, Zannad F, Amir O, Chioncel O, Leiro MC, Drozdz J, Erglis A, Fazlibegovic E, Fonseca C, Fruhwald F, Gatzov P, Goncalvesova E, Hassanein M, Hradec J, Kavoliuniene A, Lainscak M, Logeart D, Merkely B, Metra M, Persson H, Seferovic P, Temizhan A, Tousoulis D, Tavazzi L, Heart Failure Association of the ESC (2013) Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12 440 patients of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail 15:1173–1184
doi: 10.1093/eurjhf/hft134
Gabet A, Juillière Y, Lamarche-Vadel A, Vernay M, Olié V (2015) National trends in rate of patients hospitalized for heart failure and heart failure mortality in France, 2000–2012. Eur J Heart Fail 17:583–590
doi: 10.1002/ejhf.284
Omersa D, Farkas J, Erzen I, Lainscak M (2016) National trends in heart failure hospitalization rates in Slovenia 2004–2012. Eur J Heart Fail 18:1321–1328
doi: 10.1002/ejhf.617
Christ M, Störk S, Dörr M, Heppner HJ, Müller C, Wachter R, Riemer U, Trend HF Germany Project (2016) Heart failure epidemiology 2000–2013: insights from the German Federal Health Monitoring System. Eur J Heart Fail 18:1009–1018
doi: 10.1002/ejhf.567
Christiansen MN, Køber L, Weeke P, Vasan RS, Jeppesen JL, Smith JG et al (2017) Age-specific trends in incidence, mortality, and comorbidities of heart failure in Denmark, 1995 to 2012. Circulation 135:1214–1223
doi: 10.1161/CIRCULATIONAHA.116.025941
Giannakouris K (2008) Population and social conditions. Eurostat Stat Focus 72:1–11
Pickard L, Comas-Herrera A, Costa-Font J, Gori C, di Maio A, Patxot C et al (2007) Modelling an entitlement to long-term care services for older people in Europe: projections for long-term care expenditure to 2050. J Eur Soc Policy 17:33–48
doi: 10.1177/0958928707071879
Onder G, Carpenter I, Finne-Soveri H, Gindin J, Frijters D, Henrard JC et al (2012) Assessment of nursing home residents in Europe: the Services and Health for Elderly in Long TERm care (SHELTER) study. BMC Health Serv Res 12:5. https://doi.org/10.1186/1472-6963-12-5
doi: 10.1186/1472-6963-12-5
pubmed: 22230771
pmcid: 3286368
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P, Authors/Task Force Members, Document Reviewers (2016) 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 18:891–975
doi: 10.1002/ejhf.592
Heckman GA, Shamji AK, Ladha R, Stapleton J, Boscart V, Boxer RS, Martin LB, Crutchlow L, McKelvie R (2018) Heart failure management in nursing homes: a scoping literature review. Can J Cardiol 34:871–880
doi: 10.1016/j.cjca.2018.04.006
Daamen MA, Schols JM, Jaarsma T, Hamers JP (2008) Prevalence of heart failure in nursing homes: a systematic literature review. Scand J Caring Sci 24:202–208
doi: 10.1111/j.1471-6712.2009.00708.x
Barents M, van der Horst IC, Voors AA, Hillege JL, Muskiet FA, De Jongste MJ (2008) Prevalence and misdiagnosis of chronic heart failure in nursing home residents: the role of B-type natriuretic peptides. Neth Heart J 16:123–128
doi: 10.1007/BF03086130
Hancock HC, Close H, Mason JM, Murphy JJ, Fuat A, Singh R, Wood E, de Belder M, Brennan G, Hussain N, Kumar N, Wilson D, Hungin AP (2013) High prevalence of undetected heart failure in long-term care residents: findings from the Heart Failure in Care Homes (HFinCH) study. Eur J Heart Fail 15:158–165
doi: 10.1093/eurjhf/hfs165
Foebel AD, Heckman GA, Ji K, Dubin JA, Turpie ID, Hussack P, McKelvie R (2013) Heart failure–related mortality and hospitalization in the year following admission to a long-term care facility: the Geriatric Outcomes and Longitudinal Decline in Heart Failure (GOLD-HF) Study. J Card Fail 19:468–477
doi: 10.1016/j.cardfail.2013.05.003
Mueller C, McDonald K, de Boer RA, Maisel A, Cleland JG, Kozhuharov N, Coats AJS, Metra M, Mebazaa A, Ruschitzka F, Lainscak M, Filippatos G, Seferovic PM, Meijers WC, Bayes-Genis A, Mueller T, Richards M, Januzzi JL Jr, Heart Failure Association of the European Society of Cardiology (2019) Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations. Eur J Heart Fail 21:715–731
doi: 10.1002/ejhf.1494
Oudejans I, Mosterd A, Bloemen JA, Valk MJ, van Velzen E, Wielders JP, Zuithoff NP, Rutten FH, Hoes AW (2011) Clinical evaluation of geriatric outpatients with suspected heart failure: value of symptoms, signs, and additional tests. Eur J Heart Fail 13:518–527
doi: 10.1093/eurjhf/hfr021
Taylor KS, Verbakel JY, Feakins BG, Price CP, Perera R, Bankhead C et al (2018) Diagnostic accuracy of point-of-care natriuretic peptide testing for chronic heart failure in ambulatory care: systematic review and meta-analysis. BMJ 361:k1450
doi: 10.1136/bmj.k1450
Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, Ioannidis JP, Straus S, Thorlund K, Jansen JP, Mulrow C, Catalá-López F, Gøtzsche PC, Dickersin K, Boutron I, Altman DG, Moher D (2015) The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 162:777–784
doi: 10.7326/M14-2385
Higgins JP, Green S (2008) Cochrane handbook for systematic reviews of interventions [Internet]. John Wiley & Sons, Ltd, Chichester. https://doi.org/10.1002/9780470712184 [cited 2019 Sep 7]
doi: 10.1002/9780470712184
Daamen MA, Hamers JP, Gorgels AP, Brunner-la Rocca H-P, Tan FE, van Dieijen-Visser MP, Schols JM (2012) The prevalence and management of heart failure in Dutch nursing homes; design of a multi-centre cross-sectional study. BMC Geriatr 12:29. https://doi.org/10.1186/1471-2318-12-29
doi: 10.1186/1471-2318-12-29
pubmed: 22686685
pmcid: 3462700
Sanders-van Wijk S, van Asselt AD, Rickli H, Estlinbaum W, Erne P, Rickenbacher P, Vuillomenet A, Peter M, Pfisterer ME, Brunner-la Rocca HP, TIME-CHF Investigators (2013) Cost-effectiveness of N-terminal pro-B-type natriuretic-guided therapy in elderly heart failure patients: results from TIME-CHF (Trial of Intensified versus Standard Medical Therapy in Elderly Patients with Congestive Heart ailure). JACC Heart Fail 1:64–71
doi: 10.1016/j.jchf.2012.08.002
Bolmsjö BB, Mölstad S, Östgren CJ, Midlöv P (2013) Prevalence and treatment of heart failure in Swedish nursing homes. BMC Geriatr 13:118–119. https://doi.org/10.1186/1471-2318-13-118
doi: 10.1186/1471-2318-13-118
pubmed: 24188665
pmcid: 4228246
Barents M, Hillege HH, van der Horst IC, de Boer RA, Koster J, Muskiet FA et al (2008) BNP and NT-proBNP, predictors of 1-year mortality in nursing home residents. J Am Med Dir Assoc 9:580–585
doi: 10.1016/j.jamda.2008.05.002
Valle R, Aspromonte N, Barro S, Canali C, Carbonieri E, Ceci V et al (2005) The NT-proBNP assay identifies very elderly nursing home residents suffering from pre-clinical heart failure. Eur J Heart Fail 7:542–551
doi: 10.1016/j.ejheart.2004.07.005
Mason JM, Hancock HC, Close H, Murphy JJ, Fuat A, de Belder M et al (2013) Utility of biomarkers in the differential diagnosis of heart failure in older people: findings from the Heart Failure in Care Homes (HFinCH) Diagnostic Accuracy Study. PLoS One 8:e53560
doi: 10.1371/journal.pone.0053560
Daamen MA, Hamers JP, Gorgels AP, Brunner-La Rocca H-P, Tan FE, van Dieijen-Visser MP et al (2015) Heart failure in nursing home residents; a cross-sectional study to determine the prevalence and clinical characteristics. BMC Geriatr 15:167. https://doi.org/10.1186/s12877-015-0166-1
doi: 10.1186/s12877-015-0166-1
pubmed: 26675117
pmcid: 4681153
Vidán MT, Sánchez E, Fernández-Avilés F, Serra-Rexach JA, Ortiz J, Bueno H (2014) FRAIL-HF, a study to evaluate the clinical complexity of heart failure in nondependent older patients: rationale, methods and baseline characteristics. Clin Cardiol 37:725–732
doi: 10.1002/clc.22345
Vidán MT, Blaya-Novakova V, Sánchez E, Ortiz J, Serra-Rexach JA, Bueno H (2016) Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure. Eur J Heart Fail 18:869–875
doi: 10.1002/ejhf.518
Sharpe N, Doughty R (1998) Epidemiology of heart failure and ventricular dysfunction. Lancet 352:SI3–SI7
doi: 10.1016/S0140-6736(98)90012-5
Cleland JG, Swedberg K, Poole-Wilson PA (1998) Successes and failures of current treatment of heart failure. Lancet 352:SI19–SI28
doi: 10.1016/S0140-6736(98)90015-0
Bugge C, Sether EM, Pahle A, Halvorsen S, Sonbo Kristiansen I (2018) Diagnosing heart failure with NT-proBNP point-of-care testing: lower costs and better outcomes. A decision analytic study. BJGP Open 2(3). https://doi.org/10.3399/bjgpopen18X101596 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189780/ . Accessed 2 Sept 2019
Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Wilson PW et al (2004) Impact of obesity on plasma natriuretic peptide levels. Circulation 109:594–600
doi: 10.1161/01.CIR.0000112582.16683.EA
Buckley LF, Canada JM, Del Buono MG, Carbone S, Trankle CR, Billingsley H et al (2018) Low NT-proBNP levels in overweight and obese patients do not rule out a diagnosis of heart failure with preserved ejection fraction. ESC Heart Fail 5:372–378
doi: 10.1002/ehf2.12235
Johnston N, Jernberg T, Lindahl B, Lindbäck J, Stridsberg M, Larsson A et al (2004) Biochemical indicators of cardiac and renal function in a healthy elderly population. Clin Biochem 37:210–216
doi: 10.1016/j.clinbiochem.2003.11.002
Hildebrandt P, Collinson PO, Doughty RN, Fuat A, Gaze DC, Gustafsson F, Januzzi J, Rosenberg J, Senior R, Richards M (2010) Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care. Eur Heart J 31:1881–1889
doi: 10.1093/eurheartj/ehq163
Januzzi JL, Chen-Tournoux AA, Christenson RH, Doros G, Hollander JE, Levy PD et al (2018) N-terminal pro-B-type natriuretic peptide in the emergency department: the ICON-RELOADED Study. J Am Coll Cardiol 71:1191–1200
doi: 10.1016/j.jacc.2018.01.021
Chioncel O, Lainscak M, Seferovic PM, Anker SD, Crespo-Leiro MG, Harjola V-P, Parissis J, Laroche C, Piepoli MF, Fonseca C, Mebazaa A, Lund L, Ambrosio GA, Coats AJ, Ferrari R, Ruschitzka F, Maggioni AP, Filippatos G (2017) Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail 19:1574–1585
doi: 10.1002/ejhf.813