Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of


Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
07 04 2020
Historique:
entrez: 24 3 2020
pubmed: 24 3 2020
medline: 9 3 2021
Statut: ppublish

Résumé

Background Renal artery stenosis is a common cause of renal ischemia, contributing to the development of chronic kidney disease. To investigate the role of local CD40 expression in renal artery stenosis, Goldblatt 2-kidney 1-clip surgery was performed on hypertensive Dahl salt-sensitive rats (S rats) and genetically modified S rats in which CD40 function is abolished (

Identifiants

pubmed: 32200719
doi: 10.1161/JAHA.119.014072
pmc: PMC7428653
doi:

Substances chimiques

CD40 Antigens 0
Inflammation Mediators 0
Plasminogen Activator Inhibitor 1 0
Serpine1 protein, rat 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e014072

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL137004
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105649
Pays : United States

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Auteurs

Shungang Zhang (S)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Joshua D Breidenbach (JD)

Department of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH.

Fatimah K Khalaf (FK)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Prabhatchandra R Dube (PR)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Chrysan J Mohammed (CJ)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Apurva Lad (A)

Department of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH.

Stanislaw Stepkowski (S)

Department of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH.

Terry D Hinds (TD)

Department of Physiology and Pharmacology University of Toledo College of Medicine and Life Sciences Toledo OH.

Sivarajan Kumarasamy (S)

Department of Physiology and Pharmacology University of Toledo College of Medicine and Life Sciences Toledo OH.

Andrew Kleinhenz (A)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Jiang Tian (J)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Deepak Malhotra (D)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

David J Kennedy (DJ)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Christopher J Cooper (CJ)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

Steven T Haller (ST)

Department of Medicine University of Toledo College of Medicine and Life Sciences Toledo OH.

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