Lysine-specific demethylase 3A is important for autophagic occurrence.
Autophagy
H3K9 demethylation
KDM3A
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
21 05 2020
21 05 2020
Historique:
received:
23
02
2020
accepted:
10
03
2020
pubmed:
24
3
2020
medline:
25
11
2020
entrez:
24
3
2020
Statut:
ppublish
Résumé
Autophagy is an essential process to maintain cell survival and homeostasis under various stress conditions. Here, we report that lysine-specific demethylase 3A (KDM3A) plays an important role in starvation-induced autophagy. Using Kdm3a knockout mice, we demonstrate that KDM3A is crucial for proper hepatic autophagy in vivo. Hepatic mRNA expression analysis and ChIP assay in WT and Kdm3a knockout mouse livers reveal that KDM3A activates autophagy genes by reducing histone H3K9me2 levels upon fasting. Together, our finding represents previously unidentified function of KDM3A as a key regulator of autophagy, implicating potential therapeutic approaches for autophagy-related diseases.
Identifiants
pubmed: 32201075
pii: S0006-291X(20)30543-X
doi: 10.1016/j.bbrc.2020.03.058
pii:
doi:
Substances chimiques
RNA, Messenger
0
Jumonji Domain-Containing Histone Demethylases
EC 1.14.11.-
Kdm3a protein, mouse
EC 1.14.11.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
176-183Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.