Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
Chondrocytes
Chondroitin sulfate
Endochondral ossification
Ext1
Extracellular matrix
Heparan sulfate
Hs2st1
Journal
Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
26
08
2019
revised:
11
03
2020
accepted:
12
03
2020
pubmed:
24
3
2020
medline:
24
8
2021
entrez:
24
3
2020
Statut:
ppublish
Résumé
Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones. Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes. To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce either reduced levels of HS (Ext1
Identifiants
pubmed: 32201365
pii: S0945-053X(20)30029-9
doi: 10.1016/j.matbio.2020.03.006
pii:
doi:
Substances chimiques
Chondroitin Sulfates
9007-28-7
Heparitin Sulfate
9050-30-0
N-Acetylglucosaminyltransferases
EC 2.4.1.-
exostosin-1
EC 2.4.1.224
Sulfotransferases
EC 2.8.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-59Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration Competing of Interest The authors declare no conflict of interest.