Synthesis and characterization of cecropin peptide-based silver nanocomposites: Its antibacterial activity and mode of action.

Novel antimicrobial agents with a low propensity to develop resistance by microorganisms have contemporary relevance. In this perspective, the present study reports the green synthesis and characterization of cecropins peptides (D2A21, D2A10, and D4E1) based silver nanocomposites. The effect of pH and concentration of peptides on the formation of nanocomposite material was studied using UV-Vis spectroscopy. The particle size was determined by transmission electron microscopy, which indicated the size in the range of 3 ± 0.4 to 20 ± 5 nm. Fourier-transform infrared spectroscopy studies suggested the involvement of peptides as a capping and reducing agent. Zeta potential analysis suggested that nanocomposite material was more cationic in nature than its native peptides. Nanocomposite material exhibited significantly enhanced antibacterial activity as compared to native peptides and silver nanoparticles with minimum inhibitory concentration (MIC) ranging from 1 to 3 μg mL

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Declaration of competing interest All authors certify that they have no conflict of interest in relation to the subject matter or materials discussed in this manuscript.