Identification of Predictive Factors for Mechanical Complications After Adult Spinal Deformity Surgery: A Multi-Institutional Retrospective Study.


Journal

Spine
ISSN: 1528-1159
Titre abrégé: Spine (Phila Pa 1976)
Pays: United States
ID NLM: 7610646

Informations de publication

Date de publication:
01 Sep 2020
Historique:
pubmed: 25 3 2020
medline: 17 12 2020
entrez: 25 3 2020
Statut: ppublish

Résumé

A retrospective multicenter observational study. To investigate correction surgeries that were performed in relatively aged patients in terms of mechanical complications (MCs) and their predictive factors. The risk factors associated with MCs have not yet been well examined, especially in aged populations. We retrospectively reviewed 230 surgically treated ASD patients with an average age of 72.2 years. Twenty-eight patients with ASD caused by vertebral fractures were excluded. The minimum follow-up was 2 years. Postoperative MCs were defined as proximal junction kyphosis, distal junction kyphosis, pseudoarthrosis, rod breakage, and vertebral fractures. We divided all the ASD patients into two groups: patients with MC (the MC (+) group) and patients without MC (the MC (-) group). Radiographic parameters were evaluated before and immediately after surgery. The SRS-Schwab ASD classification and global alignment and proportion (GAP) score were also evaluated. Of the 202 patients, 91 (45.0%) had MCs. The age at surgery was significantly higher in the MC (+) group than in the MC (-) group. Regarding radiographic parameters, postoperative global tilt (GT), pre- and postoperative thoracolumbar kyphosis (TLK), and postoperative thoracic kyphosis were significantly higher in the MC (+) group than in the MC (-) group. Other parameters, such as the proposed ideal alignment target of PI-LL<10, did not significantly affect MC rates. The GAP score was high in both groups and not significantly related to a higher rate of MC. Forward stepwise logistic regression indicated that the age at surgery, postoperative GT, and preoperative TLK were significant risk factors for MCs. Older age, higher postoperative GT, and higher pre and postoperative TLK can be risk factors for MCs. The GAP score was high in both groups and not significantly related to a higher rate of MC. 4.

Sections du résumé

STUDY DESIGN METHODS
A retrospective multicenter observational study.
OBJECTIVE OBJECTIVE
To investigate correction surgeries that were performed in relatively aged patients in terms of mechanical complications (MCs) and their predictive factors.
SUMMARY OF BACKGROUND DATA BACKGROUND
The risk factors associated with MCs have not yet been well examined, especially in aged populations.
METHODS METHODS
We retrospectively reviewed 230 surgically treated ASD patients with an average age of 72.2 years. Twenty-eight patients with ASD caused by vertebral fractures were excluded. The minimum follow-up was 2 years. Postoperative MCs were defined as proximal junction kyphosis, distal junction kyphosis, pseudoarthrosis, rod breakage, and vertebral fractures. We divided all the ASD patients into two groups: patients with MC (the MC (+) group) and patients without MC (the MC (-) group). Radiographic parameters were evaluated before and immediately after surgery. The SRS-Schwab ASD classification and global alignment and proportion (GAP) score were also evaluated.
RESULTS RESULTS
Of the 202 patients, 91 (45.0%) had MCs. The age at surgery was significantly higher in the MC (+) group than in the MC (-) group. Regarding radiographic parameters, postoperative global tilt (GT), pre- and postoperative thoracolumbar kyphosis (TLK), and postoperative thoracic kyphosis were significantly higher in the MC (+) group than in the MC (-) group. Other parameters, such as the proposed ideal alignment target of PI-LL<10, did not significantly affect MC rates. The GAP score was high in both groups and not significantly related to a higher rate of MC. Forward stepwise logistic regression indicated that the age at surgery, postoperative GT, and preoperative TLK were significant risk factors for MCs.
CONCLUSION CONCLUSIONS
Older age, higher postoperative GT, and higher pre and postoperative TLK can be risk factors for MCs. The GAP score was high in both groups and not significantly related to a higher rate of MC.
LEVEL OF EVIDENCE METHODS
4.

Identifiants

pubmed: 32205686
doi: 10.1097/BRS.0000000000003500
pii: 00007632-202009010-00007
doi:

Types de publication

Journal Article Multicenter Study Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

1185-1192

Références

Scheer JK, Hostin R, Robinson C, et al. Operative management of adult spinal deformity results in significant increases in qalys gained compared to nonoperative management: analysis of 479 patients with minimum 2-year follow-up. Spine (Phila Pa 1976) 2018; 43:339–347.
Schwab FJ, Blondel B, Bess S, et al. Radiographical spinopelvic parameters and disability in the setting of adult spinal deformity: a prospective multicenter analysis. Spine (Phila Pa 1976) 2013; 38:E803–E812.
Bridwell KH, Glassman S, Horton W, et al. Does treatment (nonoperative and operative) improve the two-year quality of life in patients with adult symptomatic lumbar scoliosis: a prospective multicenter evidence-based medicine study. Spine (Phila Pa 1976) 2009; 34:2171–2178.
Acaroglu E, Yavuz AC, Guler UO, et al. A decision analysis to identify the ideal treatment for adult spinal deformity: is surgery better than non-surgical treatment in improving health-related quality of life and decreasing the disease burden? Eur Spine J 2016; 25:2390–2400.
Charosky S, Guigui P, Blamoutier A, et al. Complications and risk factors of primary adult scoliosis surgery: a multicenter study of 306 patients. Spine (Phila Pa 1976) 2012; 37:693–700.
Hallager DW, Karstensen S, Bukhari N, et al. Radiographic predictors for mechanical failure after adult spinal deformity surgery: a retrospective cohort study in 138 patients. Spine (Phila Pa 1976) 2017; 42:E855–E863.
Glassman SD, Bridwell K, Dimar JR, et al. The impact of positive sagittal balance in adult spinal deformity. Spine (Phila Pa 1976) 2005; 30:2024–2029.
Cho SK, Bridwell KH, Lenke LG, et al. Major complications in revision adult deformity surgery: risk factors and clinical outcomes with 2- to 7-year follow-up. Spine (Phila Pa 1976) 2012; 37:489–500.
Soroceanu A, Burton DC, Oren JH, et al. Medical complications after adult spinal deformity surgery: incidence, risk factors, and clinical impact. Spine (Phila Pa 1976) 2016; 41:1718–1723.
Jacobs E, van Royen BJ, van Kuijk SMJ, et al. Prediction of mechanical complications in adult spinal deformity surgery-the GAP score versus the Schwab classification. Spine J 2019; 19:781–788.
Yilgor C, Sogunmez N, Boissiere L, et al. Global alignment and proportion (GAP) score: development and validation of a new method of analyzing spinopelvic alignment to predict mechanical complications after adult spinal deformity surgery. J Bone Joint Surg Am 2017; 99:1661–1672.
Yilgor C, Sogunmez N, Yavuz Y, et al. Relative lumbar lordosis and lordosis distribution index: individualized pelvic incidence-based proportional parameters that quantify lumbar lordosis more precisely than the concept of pelvic incidence minus lumbar lordosis. Neurosurg Focus 2017; 43:E5.
Boissière L, Takemoto M, Bourghli A, et al. Global tilt and lumbar lordosis index: two parameters correlating with health-related quality of life scores-but how do they truly impact disability? Spine J 2017; 17:480–488.
Obeid I, Boissière L, Yilgor C, et al. Global tilt: a single parameter incorporating spinal and pelvic sagittal parameters and least affected by patient positioning. Eur Spine J 2016; 25:3644–3649.
Inoue S, Khashan M, Fujimori T, et al. Analysis of mechanical failure associated with reoperation in spinal fusion to the sacrum in adult spinal deformity. J Orthop Sci 2015; 20:609–616.
Bari TJ, Ohrt-Nissen S, Hansen LV, et al. Ability of the global alignment and proportion score to predict mechanical failure following adult spinal deformity surgery-validation in 149 patients with two-year follow-up. Spine Deform 2019; 7:331–337.
Iyer S, Lenke LG, Nemani VM, et al. Variations in sagittal alignment parameters based on age: a prospective study of asymptomatic volunteers using full-body radiographs. Spine (Phila Pa 1976) 2016; 41:1826–1836.
Maruo K, Ha Y, Inoue S, et al. Predictive factors for proximal junctional kyphosis in long fusions to the sacrum in adult spinal deformity. Spine (Phila Pa 1976) 2013; 38:E1469–E1476.
Smith JS, Shaffrey CI, Glassman SD, et al. Risk-benefit assessment of surgery for adult scoliosis: an analysis based on patient age. Spine (Phila Pa 1976) 2011; 36:817–824.
Yagi M, Fujita N, Okada E, et al. Clinical outcomes, complications, and cost-effectiveness in surgically treated adult spinal deformity over 70 years: a propensity score-matched analysis. Clin Spine Surg 2019; 33:E14–E20.
Yagi M, Fujita N, Tsuji O, et al. Low bone-mineral density is a significant risk for proximal junctional failure after surgical correction of adult spinal deformity: a propensity score-matched analysis. Spine (Phila Pa 1976) 2018; 43:485–491.
Pennington Z, Cottrill E, Ahmed AK, et al. Paraspinal muscle size as an independent risk factor for proximal junctional kyphosis in patients undergoing thoracolumbar fusion. J Neurosurg Spine 2019; 31:380–388.
Amin RM, Raad M, Jain A, et al. Increasing body mass index is associated with worse perioperative outcomes and higher costs in adult spinal deformity surgery. Spine (Phila Pa 1976) 2018; 43:693–698.
Soroceanu A, Burton DC, Diebo BG, et al. Impact of obesity on complications, infection, and patient-reported outcomes in adult spinal deformity surgery. J Neurosurg Spine 2015; 23:656–664.
Yagi M, Ohne H, Konomi T, et al. Teriparatide improves volumetric bone mineral density and fine bone structure in the UIV+1 vertebra, and reduces bone failure type PJK after surgery for adult spinal deformity. Osteoporos Int 2016; 27:3495–3502.
Seki S, Hirano N, Kawaguchi Y, et al. Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis. Eur Spine J 2017; 26:2121–2127.
Macagno AE, O’Brien MF. Thoracic and thoracolumbar kyphosis in adults. Spine (Phila Pa 1976) 2006; 31:S161–S170.
Lafage R, Schwab F, Glassman S, et al. Age-adjusted alignment goals have the potential to reduce PJK. Spine (Phila Pa 1976) 2017; 42:1275–1282.

Auteurs

Atsuyuki Kawabata (A)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Toshitaka Yoshii (T)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Kenichiro Sakai (K)

Department of Orthopedic Surgery, Saiseikai Kawaguchi General Hospital, Kawaguchi, Saitama, Japan.

Takashi Hirai (T)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Masato Yuasa (M)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Hiroyuki Inose (H)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Kurando Utagawa (K)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Jun Hashimoto (J)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Yu Matsukura (Y)

Department of Orthopedic Surgery, Saiseikai Kawaguchi General Hospital, Kawaguchi, Saitama, Japan.

Masaki Tomori (M)

Department of Orthopedic Surgery, Saiseikai Kawaguchi General Hospital, Kawaguchi, Saitama, Japan.

Ichiro Torigoe (I)

Department of Orthopedic Surgery, Saiseikai Kawaguchi General Hospital, Kawaguchi, Saitama, Japan.

Kazuo Kusano (K)

Department of Orthopedic Surgery, Kudanzaka Hospital, Chiyoda, Tokyo, Japan.

Kazuyuki Otani (K)

Department of Orthopedic Surgery, Kudanzaka Hospital, Chiyoda, Tokyo, Japan.

Koichi Mizuno (K)

Department of Orthopedic Surgery, Kudanzaka Hospital, Chiyoda, Tokyo, Japan.

Sumiya Satoshi (S)

Department of Orthopedic Surgery, Saku Medical Center, Saku, Nagano, Japan.

Fukushima Kazuyuki (F)

Department of Orthopedic Surgery, Saku Medical Center, Saku, Nagano, Japan.

Shoji Tomizawa (S)

Department of Orthopedic Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Chiba, Japan.

Yoshiyasu Arai (Y)

Department of Orthopedic Surgery, Saiseikai Kawaguchi General Hospital, Kawaguchi, Saitama, Japan.

Shigeo Shindo (S)

Department of Orthopedic Surgery, Kudanzaka Hospital, Chiyoda, Tokyo, Japan.

Atsushi Okawa (A)

Department of Orthopedic Surgery, Tokyo Medical and Dental University, Bunkyo City, Tokyo, Japan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH