Exosomes-carried microRNA-26b-5p regulates microglia M1 polarization after cerebral ischemia/reperfusion.
Animals
Brain Ischemia
/ metabolism
Cell Hypoxia
Cell Polarity
/ genetics
Coculture Techniques
Disease Models, Animal
Exosomes
/ metabolism
Glucose
/ deficiency
Humans
Mesenchymal Stem Cells
/ metabolism
Mice
Mice, Inbred BALB C
MicroRNAs
/ genetics
Microglia
/ metabolism
PC12 Cells
Rats
Reperfusion Injury
/ metabolism
Steroid Hydroxylases
/ metabolism
Transfection
CH25H
Ischemia/reperfusion
M1 microglia
exosome
human umbilical cord mesenchymal stem cell
microRNA-26b-5p
Journal
Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Titre abrégé: Cell Cycle
Pays: United States
ID NLM: 101137841
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
27
3
2020
medline:
31
7
2021
entrez:
27
3
2020
Statut:
ppublish
Résumé
Exosome and microRNAs (miRs) are implicated in ischemia/reperfusion (I/R) process. In this study, I/R mouse model was established, and exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) were isolated, identified, and injected to I/R mice to observe nerve injury and microglia M1 polarization. The differentially expressed genes in I/R microglia from databases were analyzed, and miRs differentially expressed in exosomes-treated microglia were analyzed by microarray. miR-26b-5p expression in hUCMSCs was intervened. Besides, microglia was extracted and co-cultured with SH-SY5Y or PC12 cells in oxygen-glucose deprivation/reperfusion (OGD/R) models to simulate I/R
Identifiants
pubmed: 32208888
doi: 10.1080/15384101.2020.1743912
pmc: PMC7217376
doi:
Substances chimiques
MIRN26A microRNA, human
0
MicroRNAs
0
Steroid Hydroxylases
EC 1.14.-
cholesterol 25-hydroxylase
EC 1.14.99.38
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
1022-1035Commentaires et corrections
Type : RetractionIn
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