Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Alveolar Epithelial Cells
/ drug effects
Animals
Apoptosis
/ drug effects
Asbestos
/ administration & dosage
Asbestosis
/ etiology
Bleomycin
/ administration & dosage
DNA Damage
DNA Glycosylases
/ deficiency
DNA, Mitochondrial
/ genetics
Female
Gene Expression Regulation
Hydrogen Peroxide
/ pharmacology
Lung
/ drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mitochondria
/ drug effects
Primary Cell Culture
Protein Kinases
/ genetics
Pulmonary Fibrosis
/ chemically induced
RNA, Small Interfering
/ genetics
Signal Transduction
Titanium
/ administration & dosage
OGG1
PINK1
alveolar epithelial cell
mitochondrial DNA damage
oxidative stress
pulmonary fibrosis
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
pubmed:
27
3
2020
medline:
25
7
2020
entrez:
27
3
2020
Statut:
ppublish
Résumé
Alveolar epithelial cell (AEC) apoptosis, arising from mitochondrial dysfunction and mitophagy defects, is important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the mitochondrial (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), in preventing oxidant-induced AEC mtDNA damage and apoptosis and showed that OGG1-deficient mice have increased lung fibrosis. Herein, we determined whether mice overexpressing the mtOGG1 transgene (
Identifiants
pubmed: 32209025
doi: 10.1152/ajplung.00069.2019
pmc: PMC7272732
doi:
Substances chimiques
DNA, Mitochondrial
0
RNA, Small Interfering
0
Bleomycin
11056-06-7
Asbestos
1332-21-4
titanium dioxide
15FIX9V2JP
Hydrogen Peroxide
BBX060AN9V
Titanium
D1JT611TNE
Protein Kinases
EC 2.7.-
PTEN-induced putative kinase
EC 2.7.11.1
DNA Glycosylases
EC 3.2.2.-
Ogg1 protein, mouse
EC 3.2.2.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
L1084-L1096Subventions
Organisme : BLRD VA
ID : I01 BX000786
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134800
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL060678
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG060211
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL126609
Pays : United States
Références
JCI Insight. 2017 Feb 9;2(3):e88297
pubmed: 28194433
Gene. 2002 Mar 6;286(1):127-34
pubmed: 11943468
PLoS One. 2019 Jun 6;14(6):e0218003
pubmed: 31170232
Sci Rep. 2017 Nov 13;7(1):15444
pubmed: 29133960
Nat Commun. 2019 Sep 11;10(1):4108
pubmed: 31511525
J Pathol. 1987 Jun;152(2):109-17
pubmed: 3040951
Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1078-85
pubmed: 25795724
Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L892-8
pubmed: 21890512
Aging Cell. 2018 Apr;17(2):
pubmed: 29363258
Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L906-11
pubmed: 24142519
Transl Res. 2018 Dec;202:1-23
pubmed: 30036495
Immunity. 2016 Mar 15;44(3):582-596
pubmed: 26921108
Endocrinology. 2013 Aug;154(8):2640-9
pubmed: 23748360
J Immunol. 2016 Jul 15;197(2):504-16
pubmed: 27279371
J Vis Exp. 2011 Mar 26;(49):
pubmed: 21490570
Free Radic Biol Med. 2009 Sep 15;47(6):750-9
pubmed: 19524665
J Cell Sci. 2018 Jun 25;131(12):
pubmed: 29848661
Int J Mol Sci. 2015 Sep 07;16(9):21486-519
pubmed: 26370974
Am J Respir Crit Care Med. 2008 Oct 15;178(8):838-46
pubmed: 18635891
Nature. 2018 Sep;561(7722):258-262
pubmed: 30135585
J Lab Clin Med. 2001 May;137(5):330-9
pubmed: 11329530
Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L16-L26
pubmed: 28428174
J Clin Invest. 2015 Feb;125(2):521-38
pubmed: 25562319
J Immunol. 2017 Apr 1;198(7):2844-2853
pubmed: 28202616
Am J Pathol. 1988 Apr;131(1):156-70
pubmed: 2833103
J Biol Chem. 2003 Jan 17;278(3):1728-34
pubmed: 12424245
Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):514-9
pubmed: 9012815
Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1;317(2):L175-L187
pubmed: 31090437
Nat Rev Dis Primers. 2017 Oct 20;3:17074
pubmed: 29052582
Am J Respir Crit Care Med. 2007 Aug 1;176(3):277-84
pubmed: 17478620
Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L530-5
pubmed: 15563690
Am J Pathol. 1986 Feb;122(2):261-7
pubmed: 3004226
Am J Respir Cell Mol Biol. 2015 Jan;52(1):25-36
pubmed: 24918270
Aging Cell. 2015 Oct;14(5):774-83
pubmed: 26059457
Free Radic Biol Med. 2016 Dec;101:482-490
pubmed: 27840320
Oncogene. 2020 Jan;39(3):603-616
pubmed: 31511648
Am J Respir Crit Care Med. 2017 Dec 15;196(12):1571-1581
pubmed: 28783377
PLoS One. 2015 Mar 18;10(3):e0121246
pubmed: 25785991
J Clin Invest. 2017 Feb 1;127(2):405-414
pubmed: 28145905
J Biol Chem. 2014 Feb 28;289(9):6165-76
pubmed: 24429287
Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824
pubmed: 21471066
FASEB J. 2017 Jun;31(6):2520-2532
pubmed: 28258190
Am J Respir Cell Mol Biol. 2013 Dec;49(6):892-901
pubmed: 23885834
Nat Commun. 2018 Dec 6;9(1):5226
pubmed: 30523277
Cancer Res. 2016 Jan 1;76(1):30-4
pubmed: 26586787
Nat Med. 2018 Jan;24(1):39-49
pubmed: 29200204
Aging (Albany NY). 2019 Feb 4;11(3):933-949
pubmed: 30716719
Am J Respir Cell Mol Biol. 2013 Aug;49(2):167-79
pubmed: 23526222
Am J Physiol Heart Circ Physiol. 2018 Feb 1;314(2):H311-H321
pubmed: 29101177
Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):477-83
pubmed: 8756825
Sci Rep. 2018 Oct 5;8(1):14886
pubmed: 30291284
Mol Cell. 2019 Mar 21;73(6):1127-1137.e5
pubmed: 30772175
Nat Commun. 2014;5:3056
pubmed: 24445999